LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
The T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of these cells in the context of antigen presentation.
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2017-07-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms16001 |
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doaj-4c73c60958e443bda720387ec3ccab2c2021-05-11T07:48:43ZengNature Publishing GroupNature Communications2041-17232017-07-018111510.1038/ncomms16001LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formationMonika Raab0Yuning Lu1Karsten Kohler2Xin Smith3Klaus Strebhardt4Christopher E. Rudd5Department of Pathology, Cell Signaling Section, Tennis Court Road, University of CambridgeDepartment of Pathology, Cell Signaling Section, Tennis Court Road, University of CambridgeDepartment of Pathology, Cell Signaling Section, Tennis Court Road, University of CambridgeDepartment of Pathology, Cell Signaling Section, Tennis Court Road, University of CambridgeDepartment of Obstetrics and Gynaecology, School of Medicine, J.W. Goethe-UniversityDepartment of Pathology, Cell Signaling Section, Tennis Court Road, University of CambridgeThe T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of these cells in the context of antigen presentation.https://doi.org/10.1038/ncomms16001 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Monika Raab Yuning Lu Karsten Kohler Xin Smith Klaus Strebhardt Christopher E. Rudd |
spellingShingle |
Monika Raab Yuning Lu Karsten Kohler Xin Smith Klaus Strebhardt Christopher E. Rudd LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation Nature Communications |
author_facet |
Monika Raab Yuning Lu Karsten Kohler Xin Smith Klaus Strebhardt Christopher E. Rudd |
author_sort |
Monika Raab |
title |
LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation |
title_short |
LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation |
title_full |
LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation |
title_fullStr |
LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation |
title_full_unstemmed |
LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation |
title_sort |
lfa-1 activates focal adhesion kinases fak1/pyk2 to generate lat-grb2-skap1 complexes that terminate t-cell conjugate formation |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-07-01 |
description |
The T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of these cells in the context of antigen presentation. |
url |
https://doi.org/10.1038/ncomms16001 |
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