LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

The T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of these cells in the context of antigen presentation.

Bibliographic Details
Main Authors: Monika Raab, Yuning Lu, Karsten Kohler, Xin Smith, Klaus Strebhardt, Christopher E. Rudd
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms16001
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spelling doaj-4c73c60958e443bda720387ec3ccab2c2021-05-11T07:48:43ZengNature Publishing GroupNature Communications2041-17232017-07-018111510.1038/ncomms16001LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formationMonika Raab0Yuning Lu1Karsten Kohler2Xin Smith3Klaus Strebhardt4Christopher E. Rudd5Department of Pathology, Cell Signaling Section, Tennis Court Road, University of CambridgeDepartment of Pathology, Cell Signaling Section, Tennis Court Road, University of CambridgeDepartment of Pathology, Cell Signaling Section, Tennis Court Road, University of CambridgeDepartment of Pathology, Cell Signaling Section, Tennis Court Road, University of CambridgeDepartment of Obstetrics and Gynaecology, School of Medicine, J.W. Goethe-UniversityDepartment of Pathology, Cell Signaling Section, Tennis Court Road, University of CambridgeThe T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of these cells in the context of antigen presentation.https://doi.org/10.1038/ncomms16001
collection DOAJ
language English
format Article
sources DOAJ
author Monika Raab
Yuning Lu
Karsten Kohler
Xin Smith
Klaus Strebhardt
Christopher E. Rudd
spellingShingle Monika Raab
Yuning Lu
Karsten Kohler
Xin Smith
Klaus Strebhardt
Christopher E. Rudd
LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
Nature Communications
author_facet Monika Raab
Yuning Lu
Karsten Kohler
Xin Smith
Klaus Strebhardt
Christopher E. Rudd
author_sort Monika Raab
title LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
title_short LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
title_full LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
title_fullStr LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
title_full_unstemmed LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
title_sort lfa-1 activates focal adhesion kinases fak1/pyk2 to generate lat-grb2-skap1 complexes that terminate t-cell conjugate formation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-07-01
description The T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of these cells in the context of antigen presentation.
url https://doi.org/10.1038/ncomms16001
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AT yuninglu lfa1activatesfocaladhesionkinasesfak1pyk2togeneratelatgrb2skap1complexesthatterminatetcellconjugateformation
AT karstenkohler lfa1activatesfocaladhesionkinasesfak1pyk2togeneratelatgrb2skap1complexesthatterminatetcellconjugateformation
AT xinsmith lfa1activatesfocaladhesionkinasesfak1pyk2togeneratelatgrb2skap1complexesthatterminatetcellconjugateformation
AT klausstrebhardt lfa1activatesfocaladhesionkinasesfak1pyk2togeneratelatgrb2skap1complexesthatterminatetcellconjugateformation
AT christophererudd lfa1activatesfocaladhesionkinasesfak1pyk2togeneratelatgrb2skap1complexesthatterminatetcellconjugateformation
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