Reconstruction of respiratory variation signals from fMRI data
Functional MRI signals can be heavily influenced by systemic physiological processes in addition to local neural activity. For example, widespread hemodynamic fluctuations across the brain have been found to correlate with natural, low-frequency variations in the depth and rate of breathing over tim...
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doaj-4c7c4b3eab004c42946b58d24e5a70162020-12-17T04:47:11ZengElsevierNeuroImage1095-95722021-01-01225117459Reconstruction of respiratory variation signals from fMRI dataJorge A. Salas0Roza G. Bayrak1Yuankai Huo2Catie Chang3Corresponding author.; Department of Electrical Engineering and Computer Science, Vanderbilt University, USADepartment of Electrical Engineering and Computer Science, Vanderbilt University, USADepartment of Electrical Engineering and Computer Science, Vanderbilt University, USACorresponding author at: Department of Electrical Engineering and Computer Science, Vanderbilt University, USA.; Department of Electrical Engineering and Computer Science, Vanderbilt University, USA; Department of Biomedical Engineering, Vanderbilt University, USA; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, USAFunctional MRI signals can be heavily influenced by systemic physiological processes in addition to local neural activity. For example, widespread hemodynamic fluctuations across the brain have been found to correlate with natural, low-frequency variations in the depth and rate of breathing over time. Acquiring peripheral measures of respiration during fMRI scanning not only allows for modeling such effects in fMRI analysis, but also provides valuable information for interrogating brain-body physiology. However, physiological recordings are frequently unavailable or have insufficient quality. Here, we propose a computational technique for reconstructing continuous low-frequency respiration volume (RV) fluctuations from fMRI data alone. We evaluate the performance of this approach across different fMRI preprocessing strategies. Further, we demonstrate that the predicted RV signals can account for similar patterns of temporal variation in resting-state fMRI data compared to measured RV fluctuations. These findings indicate that fluctuations in respiration volume can be extracted from fMRI alone, in the common scenario of missing or corrupted respiration recordings. The results have implications for enriching a large volume of existing fMRI datasets through retrospective addition of respiratory variations information.http://www.sciencedirect.com/science/article/pii/S1053811920309447Respiratory variationfMRIPhysiologyResting stateMachine learning |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jorge A. Salas Roza G. Bayrak Yuankai Huo Catie Chang |
spellingShingle |
Jorge A. Salas Roza G. Bayrak Yuankai Huo Catie Chang Reconstruction of respiratory variation signals from fMRI data NeuroImage Respiratory variation fMRI Physiology Resting state Machine learning |
author_facet |
Jorge A. Salas Roza G. Bayrak Yuankai Huo Catie Chang |
author_sort |
Jorge A. Salas |
title |
Reconstruction of respiratory variation signals from fMRI data |
title_short |
Reconstruction of respiratory variation signals from fMRI data |
title_full |
Reconstruction of respiratory variation signals from fMRI data |
title_fullStr |
Reconstruction of respiratory variation signals from fMRI data |
title_full_unstemmed |
Reconstruction of respiratory variation signals from fMRI data |
title_sort |
reconstruction of respiratory variation signals from fmri data |
publisher |
Elsevier |
series |
NeuroImage |
issn |
1095-9572 |
publishDate |
2021-01-01 |
description |
Functional MRI signals can be heavily influenced by systemic physiological processes in addition to local neural activity. For example, widespread hemodynamic fluctuations across the brain have been found to correlate with natural, low-frequency variations in the depth and rate of breathing over time. Acquiring peripheral measures of respiration during fMRI scanning not only allows for modeling such effects in fMRI analysis, but also provides valuable information for interrogating brain-body physiology. However, physiological recordings are frequently unavailable or have insufficient quality. Here, we propose a computational technique for reconstructing continuous low-frequency respiration volume (RV) fluctuations from fMRI data alone. We evaluate the performance of this approach across different fMRI preprocessing strategies. Further, we demonstrate that the predicted RV signals can account for similar patterns of temporal variation in resting-state fMRI data compared to measured RV fluctuations. These findings indicate that fluctuations in respiration volume can be extracted from fMRI alone, in the common scenario of missing or corrupted respiration recordings. The results have implications for enriching a large volume of existing fMRI datasets through retrospective addition of respiratory variations information. |
topic |
Respiratory variation fMRI Physiology Resting state Machine learning |
url |
http://www.sciencedirect.com/science/article/pii/S1053811920309447 |
work_keys_str_mv |
AT jorgeasalas reconstructionofrespiratoryvariationsignalsfromfmridata AT rozagbayrak reconstructionofrespiratoryvariationsignalsfromfmridata AT yuankaihuo reconstructionofrespiratoryvariationsignalsfromfmridata AT catiechang reconstructionofrespiratoryvariationsignalsfromfmridata |
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1724380530489688064 |