Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern Ghana
Abstract Objective The alpha-thalassaemia trait has been associated with protection against severe malaria but its role in Plasmodium falciparum asexual parasite and gametocyte carriage remains unclear. This study examined association between prevalence of α-thalassaemia and P. falciparum asexual st...
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doaj-4c7ca9e453b4490189ff3782f84b3ed32020-11-25T03:02:27ZengBMCBMC Research Notes1756-05002019-03-011211510.1186/s13104-019-4181-8Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern GhanaHelena Lamptey0Michael Fokuo Ofori1Bright Adu2Kwadwo Asamoah Kusi3Emmanuel Kakra Dickson4Isabella Quakyi5Michael Alifrangis6Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartment of Biological, Environmental and Occupational Health Sciences, School of Public Health, College of Health Sciences, University of GhanaCentre for Medical Parasitology, Department of Immunology and Microbiology, University of CopenhagenAbstract Objective The alpha-thalassaemia trait has been associated with protection against severe malaria but its role in Plasmodium falciparum asexual parasite and gametocyte carriage remains unclear. This study examined association between prevalence of α-thalassaemia and P. falciparum asexual stage parasitaemia and gametocytaemia in children, pregnant women and adults, which was part of a bigger study that investigated some key factors that influence gametocyte carriage. Results Overall prevalence of heterozygous α-thalassaemia trait among all the groups was 39.0%, while 8.2% were homozygous alpha thalassaemia. Asexual parasite prevalence was significantly higher in children (P = 0.008) compared to adults and pregnant women. Of the asexual P. falciparum positive individuals, gametocyte prevalence was 38.5% (15/39) in children, 29.7% (11/37) in pregnant women and 17.4% (4/23) in adults. Heterozygous α-thalassaemic children were less likely to harbour asexual parasites, compared with normal and those deficient (OR = 0.52; 95% CI 0.28–0.97; P = 0.037) under the dominant model. These heterozygous children were also associated with reduced risk of parasitaemia compared to heterozygous adults and pregnant women. Children with heterozygous α-thalassaemia trait had reduced risk of asexual parasite carriage. There was however, no association between α-thalassaemia trait and risk of gametocyte carriage.http://link.springer.com/article/10.1186/s13104-019-4181-8Plasmodium falciparumSubmicroscopic parasitesAlpha-thalassaemiaGametocyte carriage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Helena Lamptey Michael Fokuo Ofori Bright Adu Kwadwo Asamoah Kusi Emmanuel Kakra Dickson Isabella Quakyi Michael Alifrangis |
spellingShingle |
Helena Lamptey Michael Fokuo Ofori Bright Adu Kwadwo Asamoah Kusi Emmanuel Kakra Dickson Isabella Quakyi Michael Alifrangis Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern Ghana BMC Research Notes Plasmodium falciparum Submicroscopic parasites Alpha-thalassaemia Gametocyte carriage |
author_facet |
Helena Lamptey Michael Fokuo Ofori Bright Adu Kwadwo Asamoah Kusi Emmanuel Kakra Dickson Isabella Quakyi Michael Alifrangis |
author_sort |
Helena Lamptey |
title |
Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern Ghana |
title_short |
Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern Ghana |
title_full |
Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern Ghana |
title_fullStr |
Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern Ghana |
title_full_unstemmed |
Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern Ghana |
title_sort |
association between alpha-thalassaemia trait, plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in southern ghana |
publisher |
BMC |
series |
BMC Research Notes |
issn |
1756-0500 |
publishDate |
2019-03-01 |
description |
Abstract Objective The alpha-thalassaemia trait has been associated with protection against severe malaria but its role in Plasmodium falciparum asexual parasite and gametocyte carriage remains unclear. This study examined association between prevalence of α-thalassaemia and P. falciparum asexual stage parasitaemia and gametocytaemia in children, pregnant women and adults, which was part of a bigger study that investigated some key factors that influence gametocyte carriage. Results Overall prevalence of heterozygous α-thalassaemia trait among all the groups was 39.0%, while 8.2% were homozygous alpha thalassaemia. Asexual parasite prevalence was significantly higher in children (P = 0.008) compared to adults and pregnant women. Of the asexual P. falciparum positive individuals, gametocyte prevalence was 38.5% (15/39) in children, 29.7% (11/37) in pregnant women and 17.4% (4/23) in adults. Heterozygous α-thalassaemic children were less likely to harbour asexual parasites, compared with normal and those deficient (OR = 0.52; 95% CI 0.28–0.97; P = 0.037) under the dominant model. These heterozygous children were also associated with reduced risk of parasitaemia compared to heterozygous adults and pregnant women. Children with heterozygous α-thalassaemia trait had reduced risk of asexual parasite carriage. There was however, no association between α-thalassaemia trait and risk of gametocyte carriage. |
topic |
Plasmodium falciparum Submicroscopic parasites Alpha-thalassaemia Gametocyte carriage |
url |
http://link.springer.com/article/10.1186/s13104-019-4181-8 |
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