Gamma-delta (γδ) T-cell lymphoma – another case unclassifiable by World Health Organization classification: a case report

• Main Authors: Hemant Sindhu, Ruqin Chen, Hui Chen, Jonathan Wong, Rashid Chaudhry, Yin Xu, Jen C. Wang
• Format: Article
• Language: English
• Published: BMC 2017-06-01
• Series: Journal of Medical Case Reports
• Subjects: Gamma-delta T-cell lymphoma (Tγδ cell lymphoma); T-cell lymphoma NOS; Case report; Hepatosplenic Tγδ; Cutaneous Tγδ
• Online Access: http://link.springer.com/article/10.1186/s13256-017-1312-5
• ISSN: 1752-1947

Abstract Background We present a case of gamma-delta T-cell lymphoma that does not fit the current World Health Organization classifications. Case presentation A 74-year-old Caribbean-American woman presented with lymphocytosis, pruritus, and non-drenching night sweats. Bone marrow and peripheral blood analyses both confirmed the diagnosis of gamma-delta T-cell lymphoma. An axillary lymph node biopsy was negative for lymphoma. Clinically absent hepatosplenomegaly and skin lesions with biopsy-proven gamma-delta T-cell lymphoma suggest that she is unclassifiable within the current classification system. Conclusions We believe this is a case of not otherwise specified gamma-delta T-cell lymphoma. Accumulation of these rare not otherwise specified cases will be important for future classification which further defines the biology of this disease.