Quinazolin-4-one derivatives lacking toxicity-producing attributes as glucokinase activators: design, synthesis, molecular docking, and in-silico ADMET prediction
Abstract Background A small library of quinazolin-4-one clubbed thiazole acetates/acetamides lacking toxicity-producing functionalities was designed, synthesized, and evaluated for antidiabetic potential as glucokinase activators (GKA). Molecular docking studies were done in the allosteric site of t...
Main Authors: | Saurabh C. Khadse, Nikhil D. Amnerkar, Manasi U. Dave, Deepak K. Lokwani, Ravindra R. Patil, Vinod G. Ugale, Nitin B. Charbe, Vivekanand A. Chatpalliwar |
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Format: | Article |
Language: | English |
Published: |
SpringerOpen
2019-12-01
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Series: | Future Journal of Pharmaceutical Sciences |
Subjects: | |
Online Access: | https://doi.org/10.1186/s43094-019-0012-y |
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