Recent advances of sonodynamic therapy in cancer treatment

• Main Authors: Guo-Yun Wan, Yang Liu, Bo-Wei Chen, Yuan-Yuan Liu, Yin-Song Wang, Ning Zhang
• Format: Article
• Language: English
• Published: China Anti-Cancer Association 2016-01-01
• Series: Cancer Biology & Medicine
• Subjects: Sonodynamic therapy; sonosensitizer; cancer; ultrasound; reactive oxygen species
• Online Access: http://www.cancerbiomed.org/index.php/cocr/article/view/953

Sonodynamic therapy (SDT) is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. In this article, we critically reviewed the currently accepted mechanisms of sonodynamic action and summarized the classification of sonosensitizers. At the same time, the breath of evidence from SDT-based studies suggests that SDT is promising for cancer treatment.