Understanding the Biocompatibility of Sintered Calcium Phosphate with Ratio of [Ca]/[P] = 1.50
Biocompatibility of sintered calcium phosphate pellets with [Ca]/[P] = 1.50 was determined in this study. Calcium pyrophosphate (CPP) phase formed on the sintered pellets immersed in a normal saline solution for 14 d at 37∘C. The intensities of hydroxyapatite (HA) reflections in the X-ray diffractio...
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Series: | Journal of Nanomaterials |
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doaj-4c84820e7f454928932fb456bb4152e42020-11-24T23:20:58ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292012-01-01201210.1155/2012/325605325605Understanding the Biocompatibility of Sintered Calcium Phosphate with Ratio of [Ca]/[P] = 1.50Feng-Lin Yen0Wei-Jen Shih1Min-Hsiung Hon2Hui-Ting Chen3I-Ming Hung4Homg-Huey Ko5Moo-Chin Wang6Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80782, TaiwanMedical Devices and Opto-Electronics Equipment Department, Metal Industries Research and Development Center, 1001 Kaonan Highway, Kaohsiung 81160, TaiwanDepartment of Materials Science and Engineering, National Cheng Kung University, 1 Ta-Hsueh Road, Tainan 70101, TaiwanDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80782, TaiwanDepartment of Chemical Engineering and Materials Science, Yuan Ze University, 135 Yuan-Tung Road, Chungli, Taiyunn 320, TaiwanDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80782, TaiwanDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80782, TaiwanBiocompatibility of sintered calcium phosphate pellets with [Ca]/[P] = 1.50 was determined in this study. Calcium pyrophosphate (CPP) phase formed on the sintered pellets immersed in a normal saline solution for 14 d at 37∘C. The intensities of hydroxyapatite (HA) reflections in the X-ray diffraction (XRD) patterns of the pellets were retrieved to as-sintered state. The pellet surface morphology shows that CPP crystallites were clearly present and make an amorphous calcium phosphate (ACP) to discriminate against become to the area of slice join together. In addition, the intensities of the CPP reflections in the XRD patterns were the highest when the pellets were immersed for 28 d. When the CPP powders were extracted from the pellets after immersion in the solution for 14 d, the viability of 3T3 cells remained above 90% for culture times from 1 to 4 d. The pellet surface morphology observed using optical microscopy showed that the cells did not adhere to the bottom of the sintered pellets when cultured for 4 d; however, some CPP phase precipitates were formed, as confirmed by XRD. In consequence, the results suggest that the sintered HA powders are good materials for use in biomedical applications because of their good biocompatibility.http://dx.doi.org/10.1155/2012/325605 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Feng-Lin Yen Wei-Jen Shih Min-Hsiung Hon Hui-Ting Chen I-Ming Hung Homg-Huey Ko Moo-Chin Wang |
spellingShingle |
Feng-Lin Yen Wei-Jen Shih Min-Hsiung Hon Hui-Ting Chen I-Ming Hung Homg-Huey Ko Moo-Chin Wang Understanding the Biocompatibility of Sintered Calcium Phosphate with Ratio of [Ca]/[P] = 1.50 Journal of Nanomaterials |
author_facet |
Feng-Lin Yen Wei-Jen Shih Min-Hsiung Hon Hui-Ting Chen I-Ming Hung Homg-Huey Ko Moo-Chin Wang |
author_sort |
Feng-Lin Yen |
title |
Understanding the Biocompatibility of Sintered Calcium Phosphate with Ratio of [Ca]/[P] = 1.50 |
title_short |
Understanding the Biocompatibility of Sintered Calcium Phosphate with Ratio of [Ca]/[P] = 1.50 |
title_full |
Understanding the Biocompatibility of Sintered Calcium Phosphate with Ratio of [Ca]/[P] = 1.50 |
title_fullStr |
Understanding the Biocompatibility of Sintered Calcium Phosphate with Ratio of [Ca]/[P] = 1.50 |
title_full_unstemmed |
Understanding the Biocompatibility of Sintered Calcium Phosphate with Ratio of [Ca]/[P] = 1.50 |
title_sort |
understanding the biocompatibility of sintered calcium phosphate with ratio of [ca]/[p] = 1.50 |
publisher |
Hindawi Limited |
series |
Journal of Nanomaterials |
issn |
1687-4110 1687-4129 |
publishDate |
2012-01-01 |
description |
Biocompatibility of sintered calcium phosphate pellets with [Ca]/[P] = 1.50 was determined in this study. Calcium pyrophosphate (CPP) phase formed on the sintered pellets immersed in a normal saline solution for 14 d at 37∘C. The intensities of hydroxyapatite (HA) reflections in the X-ray diffraction (XRD) patterns of the pellets were retrieved to as-sintered state. The pellet surface morphology shows that CPP crystallites were clearly present and make an amorphous calcium phosphate (ACP) to discriminate against become to the area of slice join together. In addition, the intensities of the CPP reflections in the XRD patterns were the highest when the pellets were immersed for 28 d. When the CPP powders were extracted from the pellets after immersion in the solution for 14 d, the viability of 3T3 cells remained above 90% for culture times from 1 to 4 d. The pellet surface morphology observed using optical microscopy showed that the cells did not adhere to the bottom of the sintered pellets when cultured for 4 d; however, some CPP phase precipitates were formed, as confirmed by XRD. In consequence, the results suggest that the sintered HA powders are good materials for use in biomedical applications because of their good biocompatibility. |
url |
http://dx.doi.org/10.1155/2012/325605 |
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