ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE
Aim. To study the relations of polymorphic variants of the genes: АРОЕ, MTHFR, IL8, IL6, TNF-а, VEGFA, ADIPOQ, ADIROR, APOB, APOА-V, APOC-IV, LPL, LP(a), BDNF, GRM1, GRM3 and development of the first ischemic stroke (IS).Material and methods. The alleles frequencies and genotypes assessed for 20 mon...
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doaj-4cb37964e0d44c28b5b45ae4b1d58ef42021-07-28T13:51:02Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252017-10-01165273310.15829/1728-8800-2017-5-27-33492ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKEV. N. Shishkova0A. Yu. Remennik1V. N. Valyaeva2V. M. Shklovsky3T. V. Adasheva4SBHI Center for Speech Pathology and NeurorehabilitationSBHI Center for Speech Pathology and NeurorehabilitationSBHI Center for Speech Pathology and NeurorehabilitationSBHI Center for Speech Pathology and NeurorehabilitationA. I. Evdokimov Moscow State University of Medicine and Dentistry (MSUMD)Aim. To study the relations of polymorphic variants of the genes: АРОЕ, MTHFR, IL8, IL6, TNF-а, VEGFA, ADIPOQ, ADIROR, APOB, APOА-V, APOC-IV, LPL, LP(a), BDNF, GRM1, GRM3 and development of the first ischemic stroke (IS).Material and methods. The alleles frequencies and genotypes assessed for 20 mono-nucleotide polymorphic gene variants in 435 patients, who had first IS, and 229 persons with no stroke, comparable with age, gender, place of living and ethnicity. Genotyping of polymorphisms was done with the prepared TaqMan probes.Results. For polymorphisms АРОВ (rs676210) and IL8 (rs1803205) there was significant difference between groups in the variety of minor alleles and genotypes.Conclusion. There is significant relation of mononucleotide polymorphisms of the genes АРОВ (rs676210) and IL8 (rs1803205) with the development of first IS in the studied groups.https://cardiovascular.elpub.ru/jour/article/view/619ischemic strokegenetics of ischemic strokegenes polymorphism |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
V. N. Shishkova A. Yu. Remennik V. N. Valyaeva V. M. Shklovsky T. V. Adasheva |
spellingShingle |
V. N. Shishkova A. Yu. Remennik V. N. Valyaeva V. M. Shklovsky T. V. Adasheva ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE Кардиоваскулярная терапия и профилактика ischemic stroke genetics of ischemic stroke genes polymorphism |
author_facet |
V. N. Shishkova A. Yu. Remennik V. N. Valyaeva V. M. Shklovsky T. V. Adasheva |
author_sort |
V. N. Shishkova |
title |
ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE |
title_short |
ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE |
title_full |
ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE |
title_fullStr |
ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE |
title_full_unstemmed |
ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE |
title_sort |
assessment of the polymorphic genes variants of the lipid and carbohydrate metabolism, vascular inflammation and neurotransmitter system in the first ischemic stroke |
publisher |
«SILICEA-POLIGRAF» LLC |
series |
Кардиоваскулярная терапия и профилактика |
issn |
1728-8800 2619-0125 |
publishDate |
2017-10-01 |
description |
Aim. To study the relations of polymorphic variants of the genes: АРОЕ, MTHFR, IL8, IL6, TNF-а, VEGFA, ADIPOQ, ADIROR, APOB, APOА-V, APOC-IV, LPL, LP(a), BDNF, GRM1, GRM3 and development of the first ischemic stroke (IS).Material and methods. The alleles frequencies and genotypes assessed for 20 mono-nucleotide polymorphic gene variants in 435 patients, who had first IS, and 229 persons with no stroke, comparable with age, gender, place of living and ethnicity. Genotyping of polymorphisms was done with the prepared TaqMan probes.Results. For polymorphisms АРОВ (rs676210) and IL8 (rs1803205) there was significant difference between groups in the variety of minor alleles and genotypes.Conclusion. There is significant relation of mononucleotide polymorphisms of the genes АРОВ (rs676210) and IL8 (rs1803205) with the development of first IS in the studied groups. |
topic |
ischemic stroke genetics of ischemic stroke genes polymorphism |
url |
https://cardiovascular.elpub.ru/jour/article/view/619 |
work_keys_str_mv |
AT vnshishkova assessmentofthepolymorphicgenesvariantsofthelipidandcarbohydratemetabolismvascularinflammationandneurotransmittersysteminthefirstischemicstroke AT ayuremennik assessmentofthepolymorphicgenesvariantsofthelipidandcarbohydratemetabolismvascularinflammationandneurotransmittersysteminthefirstischemicstroke AT vnvalyaeva assessmentofthepolymorphicgenesvariantsofthelipidandcarbohydratemetabolismvascularinflammationandneurotransmittersysteminthefirstischemicstroke AT vmshklovsky assessmentofthepolymorphicgenesvariantsofthelipidandcarbohydratemetabolismvascularinflammationandneurotransmittersysteminthefirstischemicstroke AT tvadasheva assessmentofthepolymorphicgenesvariantsofthelipidandcarbohydratemetabolismvascularinflammationandneurotransmittersysteminthefirstischemicstroke |
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1721270874157350912 |