ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE

Aim. To study the relations of polymorphic variants of the genes: АРОЕ, MTHFR, IL8, IL6, TNF-а, VEGFA, ADIPOQ, ADIROR, APOB, APOА-V, APOC-IV, LPL, LP(a), BDNF, GRM1, GRM3 and development of the first ischemic stroke (IS).Material and methods. The alleles frequencies and genotypes assessed for 20 mon...

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Main Authors:	V. N. Shishkova, A. Yu. Remennik, V. N. Valyaeva, V. M. Shklovsky, T. V. Adasheva
Format:	Article
Language:	Russian
Published:	«SILICEA-POLIGRAF» LLC 2017-10-01
Series:	Кардиоваскулярная терапия и профилактика
Subjects:	ischemic stroke genetics of ischemic stroke genes polymorphism
Online Access:	https://cardiovascular.elpub.ru/jour/article/view/619

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spelling	doaj-4cb37964e0d44c28b5b45ae4b1d58ef42021-07-28T13:51:02Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252017-10-01165273310.15829/1728-8800-2017-5-27-33492ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKEV. N. Shishkova0A. Yu. Remennik1V. N. Valyaeva2V. M. Shklovsky3T. V. Adasheva4SBHI Center for Speech Pathology and NeurorehabilitationSBHI Center for Speech Pathology and NeurorehabilitationSBHI Center for Speech Pathology and NeurorehabilitationSBHI Center for Speech Pathology and NeurorehabilitationA. I. Evdokimov Moscow State University of Medicine and Dentistry (MSUMD)Aim. To study the relations of polymorphic variants of the genes: АРОЕ, MTHFR, IL8, IL6, TNF-а, VEGFA, ADIPOQ, ADIROR, APOB, APOА-V, APOC-IV, LPL, LP(a), BDNF, GRM1, GRM3 and development of the first ischemic stroke (IS).Material and methods. The alleles frequencies and genotypes assessed for 20 mono-nucleotide polymorphic gene variants in 435 patients, who had first IS, and 229 persons with no stroke, comparable with age, gender, place of living and ethnicity. Genotyping of polymorphisms was done with the prepared TaqMan probes.Results. For polymorphisms АРОВ (rs676210) and IL8 (rs1803205) there was significant difference between groups in the variety of minor alleles and genotypes.Conclusion. There is significant relation of mononucleotide polymorphisms of the genes АРОВ (rs676210) and IL8 (rs1803205) with the development of first IS in the studied groups.https://cardiovascular.elpub.ru/jour/article/view/619ischemic strokegenetics of ischemic strokegenes polymorphism
collection	DOAJ
language	Russian
format	Article
sources	DOAJ
author	V. N. Shishkova A. Yu. Remennik V. N. Valyaeva V. M. Shklovsky T. V. Adasheva
spellingShingle	V. N. Shishkova A. Yu. Remennik V. N. Valyaeva V. M. Shklovsky T. V. Adasheva ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE Кардиоваскулярная терапия и профилактика ischemic stroke genetics of ischemic stroke genes polymorphism
author_facet	V. N. Shishkova A. Yu. Remennik V. N. Valyaeva V. M. Shklovsky T. V. Adasheva
author_sort	V. N. Shishkova
title	ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE
title_short	ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE
title_full	ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE
title_fullStr	ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE
title_full_unstemmed	ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE
title_sort	assessment of the polymorphic genes variants of the lipid and carbohydrate metabolism, vascular inflammation and neurotransmitter system in the first ischemic stroke
publisher	«SILICEA-POLIGRAF» LLC
series	Кардиоваскулярная терапия и профилактика
issn	1728-8800 2619-0125
publishDate	2017-10-01
description	Aim. To study the relations of polymorphic variants of the genes: АРОЕ, MTHFR, IL8, IL6, TNF-а, VEGFA, ADIPOQ, ADIROR, APOB, APOА-V, APOC-IV, LPL, LP(a), BDNF, GRM1, GRM3 and development of the first ischemic stroke (IS).Material and methods. The alleles frequencies and genotypes assessed for 20 mono-nucleotide polymorphic gene variants in 435 patients, who had first IS, and 229 persons with no stroke, comparable with age, gender, place of living and ethnicity. Genotyping of polymorphisms was done with the prepared TaqMan probes.Results. For polymorphisms АРОВ (rs676210) and IL8 (rs1803205) there was significant difference between groups in the variety of minor alleles and genotypes.Conclusion. There is significant relation of mononucleotide polymorphisms of the genes АРОВ (rs676210) and IL8 (rs1803205) with the development of first IS in the studied groups.
topic	ischemic stroke genetics of ischemic stroke genes polymorphism
url	https://cardiovascular.elpub.ru/jour/article/view/619
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_version_	1721270874157350912

ASSESSMENT OF THE POLYMORPHIC GENES VARIANTS OF THE LIPID AND CARBOHYDRATE METABOLISM, VASCULAR INFLAMMATION AND NEUROTRANSMITTER SYSTEM IN THE FIRST ISCHEMIC STROKE

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