The interaction between Histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosis
Histoplasma capsulatum is an intracellular fungal pathogen that causes respiratory and systemic disease by proliferating within phagocytic cells. The binding of H. capsulatum to phagocytes may be mediated by the pathogen's cell wall carbohydrates, glucans, which consist of glucose homo and hete...
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Instituto Oswaldo Cruz, Ministério da Saúde
2009-05-01
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doaj-4cba5757c1824d77b61561cdabe9155b2020-11-24T21:28:16ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80602009-05-01104349249610.1590/S0074-02762009000300016The interaction between Histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosisPatricia GorocicaMaria Lucia TaylorNoé Alvarado-VásquezArmando Pérez-TorresRicardo LascurainEdgar ZentenoHistoplasma capsulatum is an intracellular fungal pathogen that causes respiratory and systemic disease by proliferating within phagocytic cells. The binding of H. capsulatum to phagocytes may be mediated by the pathogen's cell wall carbohydrates, glucans, which consist of glucose homo and hetero-polymers and whose glycosydic linkage types differ between the yeast and mycelial phases. The ±-1,3-glucan is considered relevant for H. capsulatum virulence, whereas the ²-1,3-glucan is antigenic and participates in the modulation of the host immune response. H. capsulatum cell wall components with lectin-like activity seem to interact with the host cell surface, while host membrane lectin-like receptors can recognize a particular fungal carbohydrate ligand. This review emphasizes the relevance of the main H. capsulatum and host carbohydrate-driven interactions that allow for binding and internalization of the fungal cell into phagocytes and its subsequent avoidance of intracellular elimination.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300016Histoplasma capsulatumcarbohydratesglucanspolysaccharidesimmunomodulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Patricia Gorocica Maria Lucia Taylor Noé Alvarado-Vásquez Armando Pérez-Torres Ricardo Lascurain Edgar Zenteno |
spellingShingle |
Patricia Gorocica Maria Lucia Taylor Noé Alvarado-Vásquez Armando Pérez-Torres Ricardo Lascurain Edgar Zenteno The interaction between Histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosis Memórias do Instituto Oswaldo Cruz. Histoplasma capsulatum carbohydrates glucans polysaccharides immunomodulation |
author_facet |
Patricia Gorocica Maria Lucia Taylor Noé Alvarado-Vásquez Armando Pérez-Torres Ricardo Lascurain Edgar Zenteno |
author_sort |
Patricia Gorocica |
title |
The interaction between Histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosis |
title_short |
The interaction between Histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosis |
title_full |
The interaction between Histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosis |
title_fullStr |
The interaction between Histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosis |
title_full_unstemmed |
The interaction between Histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosis |
title_sort |
interaction between histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosis |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
0074-0276 1678-8060 |
publishDate |
2009-05-01 |
description |
Histoplasma capsulatum is an intracellular fungal pathogen that causes respiratory and systemic disease by proliferating within phagocytic cells. The binding of H. capsulatum to phagocytes may be mediated by the pathogen's cell wall carbohydrates, glucans, which consist of glucose homo and hetero-polymers and whose glycosydic linkage types differ between the yeast and mycelial phases. The ±-1,3-glucan is considered relevant for H. capsulatum virulence, whereas the ²-1,3-glucan is antigenic and participates in the modulation of the host immune response. H. capsulatum cell wall components with lectin-like activity seem to interact with the host cell surface, while host membrane lectin-like receptors can recognize a particular fungal carbohydrate ligand. This review emphasizes the relevance of the main H. capsulatum and host carbohydrate-driven interactions that allow for binding and internalization of the fungal cell into phagocytes and its subsequent avoidance of intracellular elimination. |
topic |
Histoplasma capsulatum carbohydrates glucans polysaccharides immunomodulation |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300016 |
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