Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss
Abstract It is known that lifestyle factors affect sporadic miscarriage, but the extent of this on RPL (recurrent pregnancy loss) is less well known. A systematic review and meta-analysis was performed to assess the associations between lifestyle factors and RPL. Studies that analysed RPL in the con...
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doaj-4cd8dc42df55485696f212b331f0a04f2021-04-04T11:32:08ZengNature Publishing GroupScientific Reports2045-23222021-03-0111111010.1038/s41598-021-86445-2Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy lossKa Ying Bonnie Ng0George Cherian1Alexandra J. Kermack2Sarah Bailey3Nick Macklon4Sesh K. Sunkara5Ying Cheong6School of Human Development and Health, Faculty of Medicine, University of SouthamptonDepartment of Obstetrics and Gynaecology, Princess Anne HospitalSchool of Human Development and Health, Faculty of Medicine, University of SouthamptonDepartment of Obstetrics and Gynaecology, Princess Anne HospitalZealand University Hospital, University of CopenhagenDepartment of Women and Children’s Health, Kings College London, Guy’s HospitalSchool of Human Development and Health, Faculty of Medicine, University of SouthamptonAbstract It is known that lifestyle factors affect sporadic miscarriage, but the extent of this on RPL (recurrent pregnancy loss) is less well known. A systematic review and meta-analysis was performed to assess the associations between lifestyle factors and RPL. Studies that analysed RPL in the context of BMI, smoking, alcohol and caffeine intake were included. The primary and secondary outcomes were odds of having RPL in the general population and odds of further miscarriage, respectively. Underweight and women with BMI > 25 are at higher odds of RPL in the general population (OR 1.2, 95% CI 1.12–1.28 and OR 1.21, 95% CI 1.06–1.38, respectively). In women with RPL, having BMI > 30 and BMI > 25 has increased odds of further miscarriages (OR 1.77, 95% CI 1.25–2.50 and OR 1.35, 95% CI 1.07–1.72, respectively). The quality of the evidence for our findings was low or very low. Being underweight and BMI > 25 contributes significantly to increased risk of RPL (general population). BMI > 25 or BMI > 30 increases the risk of further miscarriages (RPL population). Larger studies addressing the effects of alcohol, cigarette smoking and caffeine on the risk of RPL with optimisation of BMI in this cohort of women are now needed.https://doi.org/10.1038/s41598-021-86445-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ka Ying Bonnie Ng George Cherian Alexandra J. Kermack Sarah Bailey Nick Macklon Sesh K. Sunkara Ying Cheong |
spellingShingle |
Ka Ying Bonnie Ng George Cherian Alexandra J. Kermack Sarah Bailey Nick Macklon Sesh K. Sunkara Ying Cheong Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss Scientific Reports |
author_facet |
Ka Ying Bonnie Ng George Cherian Alexandra J. Kermack Sarah Bailey Nick Macklon Sesh K. Sunkara Ying Cheong |
author_sort |
Ka Ying Bonnie Ng |
title |
Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss |
title_short |
Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss |
title_full |
Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss |
title_fullStr |
Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss |
title_full_unstemmed |
Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss |
title_sort |
systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-03-01 |
description |
Abstract It is known that lifestyle factors affect sporadic miscarriage, but the extent of this on RPL (recurrent pregnancy loss) is less well known. A systematic review and meta-analysis was performed to assess the associations between lifestyle factors and RPL. Studies that analysed RPL in the context of BMI, smoking, alcohol and caffeine intake were included. The primary and secondary outcomes were odds of having RPL in the general population and odds of further miscarriage, respectively. Underweight and women with BMI > 25 are at higher odds of RPL in the general population (OR 1.2, 95% CI 1.12–1.28 and OR 1.21, 95% CI 1.06–1.38, respectively). In women with RPL, having BMI > 30 and BMI > 25 has increased odds of further miscarriages (OR 1.77, 95% CI 1.25–2.50 and OR 1.35, 95% CI 1.07–1.72, respectively). The quality of the evidence for our findings was low or very low. Being underweight and BMI > 25 contributes significantly to increased risk of RPL (general population). BMI > 25 or BMI > 30 increases the risk of further miscarriages (RPL population). Larger studies addressing the effects of alcohol, cigarette smoking and caffeine on the risk of RPL with optimisation of BMI in this cohort of women are now needed. |
url |
https://doi.org/10.1038/s41598-021-86445-2 |
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