Contamination of single fluid-filled intragastric balloons with orogastric fluid is not associated with hyperinflation: an ex-vivo study and systematic review of literature
Abstract Background Spontaneous hyperinflation is reported to the Food and Drug Administration as a complication of intragastric balloons. It is postulated that orogastric contamination of the intragastric balloon may cause this phenomenon. We sought to investigate the effects of intentional balloon...
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doaj-4cdd470ea1ce4030976b1a26332b6cd22021-07-18T11:18:32ZengBMCBMC Gastroenterology1471-230X2021-07-012111910.1186/s12876-021-01863-wContamination of single fluid-filled intragastric balloons with orogastric fluid is not associated with hyperinflation: an ex-vivo study and systematic review of literatureFadi Hawa0Eric J. Vargas1Andres Acosta2Alison McRae3Fateh Bazerbachi4Barham K. Abu Dayyeh5Department of Internal Medicine, St. Joseph Mercy Ann Arbor HospitalDivision of Gastroenterology and Hepatology, Department of Medicine, Mayo ClinicDivision of Gastroenterology and Hepatology, Department of Medicine, Mayo ClinicDivision of Gastroenterology and Hepatology, Department of Medicine, Mayo ClinicDivision of Gastroenterology and Hepatology, St. Cloud HospitalDivision of Gastroenterology and Hepatology, Department of Medicine, Mayo ClinicAbstract Background Spontaneous hyperinflation is reported to the Food and Drug Administration as a complication of intragastric balloons. It is postulated that orogastric contamination of the intragastric balloon may cause this phenomenon. We sought to investigate the effects of intentional balloon contamination with gastric contents on intragastric balloon perimeter and contents, whether methylene blue plays a role in preventing spontaneous hyperinflation, and review the available literature on spontaneous hyperinflation. Methods Four pairs of balloons with different combinations of sterile saline, orogastric contaminants, and methylene blue were incubated in a 37 °C water bath for six months to simulate physiological conditions with serial measurements of balloon perimeter. Our findings were compared against a systematic review across multiple databases to summarize the available literature. Results Balloon mean perimeter decreased from 33.5 cm ± 0.53 cm to 28.5 cm ± 0.46 cm (p < 0.0001). No significant differences were seen with the methylene blue group. Only 11 cases were found reported in the literature. Conclusions Despite contaminating intragastric balloons with gastric aspirates, hyperinflation did not occur, and other factors may be in play to account for this phenomenon, when observed. Rates of hyperinflation remain under-reported in the literature. Further controlled experiments are needed.https://doi.org/10.1186/s12876-021-01863-wAdverse outcomesBariatricsBariatric surgeryEndoscopyExperimentalEx-vivo |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fadi Hawa Eric J. Vargas Andres Acosta Alison McRae Fateh Bazerbachi Barham K. Abu Dayyeh |
spellingShingle |
Fadi Hawa Eric J. Vargas Andres Acosta Alison McRae Fateh Bazerbachi Barham K. Abu Dayyeh Contamination of single fluid-filled intragastric balloons with orogastric fluid is not associated with hyperinflation: an ex-vivo study and systematic review of literature BMC Gastroenterology Adverse outcomes Bariatrics Bariatric surgery Endoscopy Experimental Ex-vivo |
author_facet |
Fadi Hawa Eric J. Vargas Andres Acosta Alison McRae Fateh Bazerbachi Barham K. Abu Dayyeh |
author_sort |
Fadi Hawa |
title |
Contamination of single fluid-filled intragastric balloons with orogastric fluid is not associated with hyperinflation: an ex-vivo study and systematic review of literature |
title_short |
Contamination of single fluid-filled intragastric balloons with orogastric fluid is not associated with hyperinflation: an ex-vivo study and systematic review of literature |
title_full |
Contamination of single fluid-filled intragastric balloons with orogastric fluid is not associated with hyperinflation: an ex-vivo study and systematic review of literature |
title_fullStr |
Contamination of single fluid-filled intragastric balloons with orogastric fluid is not associated with hyperinflation: an ex-vivo study and systematic review of literature |
title_full_unstemmed |
Contamination of single fluid-filled intragastric balloons with orogastric fluid is not associated with hyperinflation: an ex-vivo study and systematic review of literature |
title_sort |
contamination of single fluid-filled intragastric balloons with orogastric fluid is not associated with hyperinflation: an ex-vivo study and systematic review of literature |
publisher |
BMC |
series |
BMC Gastroenterology |
issn |
1471-230X |
publishDate |
2021-07-01 |
description |
Abstract Background Spontaneous hyperinflation is reported to the Food and Drug Administration as a complication of intragastric balloons. It is postulated that orogastric contamination of the intragastric balloon may cause this phenomenon. We sought to investigate the effects of intentional balloon contamination with gastric contents on intragastric balloon perimeter and contents, whether methylene blue plays a role in preventing spontaneous hyperinflation, and review the available literature on spontaneous hyperinflation. Methods Four pairs of balloons with different combinations of sterile saline, orogastric contaminants, and methylene blue were incubated in a 37 °C water bath for six months to simulate physiological conditions with serial measurements of balloon perimeter. Our findings were compared against a systematic review across multiple databases to summarize the available literature. Results Balloon mean perimeter decreased from 33.5 cm ± 0.53 cm to 28.5 cm ± 0.46 cm (p < 0.0001). No significant differences were seen with the methylene blue group. Only 11 cases were found reported in the literature. Conclusions Despite contaminating intragastric balloons with gastric aspirates, hyperinflation did not occur, and other factors may be in play to account for this phenomenon, when observed. Rates of hyperinflation remain under-reported in the literature. Further controlled experiments are needed. |
topic |
Adverse outcomes Bariatrics Bariatric surgery Endoscopy Experimental Ex-vivo |
url |
https://doi.org/10.1186/s12876-021-01863-w |
work_keys_str_mv |
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