The effect of tyrosine residues on α-synuclein fibrillation
Aggregation of the intrinsically disordered protein α-synuclein into ordered amyloid fibrils is implicated in the pathogenesis of Parkinson’s disease. To unravel the role of Tyr residues in α-synuclein fibrillation, we prepared recombinant N-terminal (Y39A) and C-terminal (Y(125,133,136)A) mutants o...
Main Authors: | Katja Pirc, Miha Škarabot, Lea Pogačnik, Eva Žerovnik, natasa poklar ulrih |
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Format: | Article |
Language: | English |
Published: |
Slovenian Chemical Society
2015-01-01
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Series: | Acta Chimica Slovenica |
Subjects: | |
Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/882 |
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