Anatomical and functional correlates of cortical motor threshold of the dominant hand
Background: Resting Motor threshold (rMT) provides information about cortical motor excitability. Interestingly, the influences of the structural or functional variability of the motor system on the rMT inter-individual variability have been poorly investigated. Objective/hypothesis: To investigate...
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Format: | Article |
Language: | English |
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Elsevier
2017-09-01
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Series: | Brain Stimulation |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X17307969 |
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doaj-4cf897d898574c9db3dc23e30e4bd76b |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Charlotte Rosso Vincent Perlbarg Romain Valabregue Mickaël Obadia Claire Kemlin-Méchin Eric Moulton Sara Leder Sabine Meunier Jean-Charles Lamy |
spellingShingle |
Charlotte Rosso Vincent Perlbarg Romain Valabregue Mickaël Obadia Claire Kemlin-Méchin Eric Moulton Sara Leder Sabine Meunier Jean-Charles Lamy Anatomical and functional correlates of cortical motor threshold of the dominant hand Brain Stimulation Transcranial magnetic stimulation Magnetic resonance imaging Motor threshold Motor cortex Premotor cortex |
author_facet |
Charlotte Rosso Vincent Perlbarg Romain Valabregue Mickaël Obadia Claire Kemlin-Méchin Eric Moulton Sara Leder Sabine Meunier Jean-Charles Lamy |
author_sort |
Charlotte Rosso |
title |
Anatomical and functional correlates of cortical motor threshold of the dominant hand |
title_short |
Anatomical and functional correlates of cortical motor threshold of the dominant hand |
title_full |
Anatomical and functional correlates of cortical motor threshold of the dominant hand |
title_fullStr |
Anatomical and functional correlates of cortical motor threshold of the dominant hand |
title_full_unstemmed |
Anatomical and functional correlates of cortical motor threshold of the dominant hand |
title_sort |
anatomical and functional correlates of cortical motor threshold of the dominant hand |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2017-09-01 |
description |
Background: Resting Motor threshold (rMT) provides information about cortical motor excitability. Interestingly, the influences of the structural or functional variability of the motor system on the rMT inter-individual variability have been poorly investigated. Objective/hypothesis: To investigate relationships between rMT and measures of brain structures and function of the motor system. The hypothesis is that cortical excitability not only depends on the primary motor cortex (M1) but also on the integration of information originating from its vicinity such as premotor (PMd and SMA) and post-central (S1) cortices. Methods: We measured brain structures, including grey and white matter properties (cortical volume and fiber coherence respectively), and functional interaction (resting-state functional connectivity-FC) in areas contributing to the corticospinal tract axons, i. e, M1, S1, SMA and PMd in the dominant hemisphere of 21 healthy subjects. Results: The rMT was inversely correlated with the FC between PMd and M1 (r = −0.496, 95%CI: −0.764; −0.081; p = 0.02) and the grey matter volume of the dominant hemisphere (r = −0.463, 95%CI: −0.746; −0.039; p = 0.03). The multiple regression analysis model retained the FC between M1 and PMd (coefficient: −25 ± 9) as well as the grey matter volume of the dominant hemisphere (coefficient: −0.15 ± 0.06) explaining 44% of the variance of the rMT (p: 0.005). When adding age and coil-to-cortex distance, two factors known to influence rMT, the model reached a R2 of 75% (p: 0.0001). Conclusions: These results underline the major role of the PMd and the cortico-cortical connections toward M1 in the excitation of the corticospinal fibers likely through trans-synaptic pathways. |
topic |
Transcranial magnetic stimulation Magnetic resonance imaging Motor threshold Motor cortex Premotor cortex |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X17307969 |
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doaj-4cf897d898574c9db3dc23e30e4bd76b2021-03-19T07:10:52ZengElsevierBrain Stimulation1935-861X2017-09-01105952958Anatomical and functional correlates of cortical motor threshold of the dominant handCharlotte Rosso0Vincent Perlbarg1Romain Valabregue2Mickaël Obadia3Claire Kemlin-Méchin4Eric Moulton5Sara Leder6Sabine Meunier7Jean-Charles Lamy8Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France; AP-HP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, F-75013, Paris, France; Corresponding author. AP-HP Urgences Cérébro-vasculaires, Hôpital Pitié-Salpêtrière, 47-83 Bd de l’Hôpital, 75013, Paris, France.Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Laboratoire d'imagerie biomédicale (LIB), F-75013, Paris, France; Bioinformatics and Biostatistics Core Facility, iCONICS, IHU-A-ICM, Institut du Cerveau et de la Moelle épinière, Paris, FranceInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France; Centre de Neuro-imagerie de Recherche, CENIR, F-75013, Paris, FranceInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France; AP-HP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, F-75013, Paris, FranceInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, FranceInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, FranceAP-HP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, F-75013, Paris, FranceInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, FranceInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France; Centre de Neuro-imagerie de Recherche, CENIR, F-75013, Paris, FranceBackground: Resting Motor threshold (rMT) provides information about cortical motor excitability. Interestingly, the influences of the structural or functional variability of the motor system on the rMT inter-individual variability have been poorly investigated. Objective/hypothesis: To investigate relationships between rMT and measures of brain structures and function of the motor system. The hypothesis is that cortical excitability not only depends on the primary motor cortex (M1) but also on the integration of information originating from its vicinity such as premotor (PMd and SMA) and post-central (S1) cortices. Methods: We measured brain structures, including grey and white matter properties (cortical volume and fiber coherence respectively), and functional interaction (resting-state functional connectivity-FC) in areas contributing to the corticospinal tract axons, i. e, M1, S1, SMA and PMd in the dominant hemisphere of 21 healthy subjects. Results: The rMT was inversely correlated with the FC between PMd and M1 (r = −0.496, 95%CI: −0.764; −0.081; p = 0.02) and the grey matter volume of the dominant hemisphere (r = −0.463, 95%CI: −0.746; −0.039; p = 0.03). The multiple regression analysis model retained the FC between M1 and PMd (coefficient: −25 ± 9) as well as the grey matter volume of the dominant hemisphere (coefficient: −0.15 ± 0.06) explaining 44% of the variance of the rMT (p: 0.005). When adding age and coil-to-cortex distance, two factors known to influence rMT, the model reached a R2 of 75% (p: 0.0001). Conclusions: These results underline the major role of the PMd and the cortico-cortical connections toward M1 in the excitation of the corticospinal fibers likely through trans-synaptic pathways.http://www.sciencedirect.com/science/article/pii/S1935861X17307969Transcranial magnetic stimulationMagnetic resonance imagingMotor thresholdMotor cortexPremotor cortex |