Pathophysiology of pulmonary hypertension in newborns: Therapeutic indications
Failure of the normal cardiopulmonary transition can lead to persistent pulmonary hypertension of the newborn. Some degree of pulmonary hypertension complicates the course of more than 10% of all neonates with respiratory failure. This review article discusses the vascular abnormalities associated w...
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doaj-4cfac5c980734be49131828219be98572020-11-25T02:10:44ZengElsevierRevista Portuguesa de Cardiologia (English Edition)2174-20492013-12-01321210051012Pathophysiology of pulmonary hypertension in newborns: Therapeutic indicationsCarina Teixeira-Mendonça0Tiago Henriques-Coelho1Faculty of Medicine of Porto University, 4202-451 Porto, PortugalDepartment of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal; Department of Pediatric Surgery, Centro Hospitalar São João, Porto, Portugal; Corresponding author.Failure of the normal cardiopulmonary transition can lead to persistent pulmonary hypertension of the newborn. Some degree of pulmonary hypertension complicates the course of more than 10% of all neonates with respiratory failure. This review article discusses the vascular abnormalities associated with neonatal pulmonary hypertension. Common therapies including inhaled nitric oxide, high frequency ventilation, surfactant, and extracorporeal life support are included. Promising new treatment approaches like phosphodiesterase inhibition and cell-targeted therapies are presented. Resumo: Uma falha na transição cardiopulmonar do feto para a vida extrauterina, pode levar ao desenvolvimento de hipertensão pulmonar persistente do recém-nascido. Mais de 10% de todos os recém-nascidos com insuficiência respiratória apresentam algum grau de hipertensão pulmonar. Neste artigo de revisão as alterações vasculares que estão associadas com a hipertensão pulmonar neonatal são apresentadas. As terapias mais comuns, como o óxido nítrico inalado, a ventilação de alta frequência, o surfactante e terapias de suporte de vida são revistas. Novas estratégias de tratamento, como a inibição de fosfodiesterases e a terapia celular direcionada são revistas. Keywords: Neonatal ventilation, Persistent pulmonary hypertension of the newborn, Fetal circulation, Vasodilators, Palavras-chave: Ventilação neonatal, Hipertensão pulmonar persistente do recém-nascido, Circulação fetal, Vasodilatadoreshttp://www.sciencedirect.com/science/article/pii/S2174204914000063 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carina Teixeira-Mendonça Tiago Henriques-Coelho |
spellingShingle |
Carina Teixeira-Mendonça Tiago Henriques-Coelho Pathophysiology of pulmonary hypertension in newborns: Therapeutic indications Revista Portuguesa de Cardiologia (English Edition) |
author_facet |
Carina Teixeira-Mendonça Tiago Henriques-Coelho |
author_sort |
Carina Teixeira-Mendonça |
title |
Pathophysiology of pulmonary hypertension in newborns: Therapeutic indications |
title_short |
Pathophysiology of pulmonary hypertension in newborns: Therapeutic indications |
title_full |
Pathophysiology of pulmonary hypertension in newborns: Therapeutic indications |
title_fullStr |
Pathophysiology of pulmonary hypertension in newborns: Therapeutic indications |
title_full_unstemmed |
Pathophysiology of pulmonary hypertension in newborns: Therapeutic indications |
title_sort |
pathophysiology of pulmonary hypertension in newborns: therapeutic indications |
publisher |
Elsevier |
series |
Revista Portuguesa de Cardiologia (English Edition) |
issn |
2174-2049 |
publishDate |
2013-12-01 |
description |
Failure of the normal cardiopulmonary transition can lead to persistent pulmonary hypertension of the newborn. Some degree of pulmonary hypertension complicates the course of more than 10% of all neonates with respiratory failure. This review article discusses the vascular abnormalities associated with neonatal pulmonary hypertension. Common therapies including inhaled nitric oxide, high frequency ventilation, surfactant, and extracorporeal life support are included. Promising new treatment approaches like phosphodiesterase inhibition and cell-targeted therapies are presented. Resumo: Uma falha na transição cardiopulmonar do feto para a vida extrauterina, pode levar ao desenvolvimento de hipertensão pulmonar persistente do recém-nascido. Mais de 10% de todos os recém-nascidos com insuficiência respiratória apresentam algum grau de hipertensão pulmonar. Neste artigo de revisão as alterações vasculares que estão associadas com a hipertensão pulmonar neonatal são apresentadas. As terapias mais comuns, como o óxido nítrico inalado, a ventilação de alta frequência, o surfactante e terapias de suporte de vida são revistas. Novas estratégias de tratamento, como a inibição de fosfodiesterases e a terapia celular direcionada são revistas. Keywords: Neonatal ventilation, Persistent pulmonary hypertension of the newborn, Fetal circulation, Vasodilators, Palavras-chave: Ventilação neonatal, Hipertensão pulmonar persistente do recém-nascido, Circulação fetal, Vasodilatadores |
url |
http://www.sciencedirect.com/science/article/pii/S2174204914000063 |
work_keys_str_mv |
AT carinateixeiramendonca pathophysiologyofpulmonaryhypertensioninnewbornstherapeuticindications AT tiagohenriquescoelho pathophysiologyofpulmonaryhypertensioninnewbornstherapeuticindications |
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