MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

The ErbB3 receptor binding protein Ebp1 binds to ribosomes and is linked to translational control. Here, the authors present the cryo-EM structure of human Ebp1 bound to a non-translating 80S ribosome and find that Ebp1 blocks the tunnel exit and recruits the rRNA expansion segment ES27L to the tunn...

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Main Authors: Klemens Wild, Milan Aleksić, Karine Lapouge, Keven D. Juaire, Dirk Flemming, Stefan Pfeffer, Irmgard Sinning
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14603-7
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spelling doaj-4d053c81525e4a33b74dd170513e50d32021-05-11T08:38:01ZengNature Publishing GroupNature Communications2041-17232020-02-0111111010.1038/s41467-020-14603-7MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segmentsKlemens Wild0Milan Aleksić1Karine Lapouge2Keven D. Juaire3Dirk Flemming4Stefan Pfeffer5Irmgard Sinning6Biochemiezentrum der Universität Heidelberg (BZH), INF 328Zentrum für Molekulare Biologie der Universität Heidelberg, INF282Biochemiezentrum der Universität Heidelberg (BZH), INF 328Biochemiezentrum der Universität Heidelberg (BZH), INF 328Biochemiezentrum der Universität Heidelberg (BZH), INF 328Zentrum für Molekulare Biologie der Universität Heidelberg, INF282Biochemiezentrum der Universität Heidelberg (BZH), INF 328The ErbB3 receptor binding protein Ebp1 binds to ribosomes and is linked to translational control. Here, the authors present the cryo-EM structure of human Ebp1 bound to a non-translating 80S ribosome and find that Ebp1 blocks the tunnel exit and recruits the rRNA expansion segment ES27L to the tunnel exit.https://doi.org/10.1038/s41467-020-14603-7
collection DOAJ
language English
format Article
sources DOAJ
author Klemens Wild
Milan Aleksić
Karine Lapouge
Keven D. Juaire
Dirk Flemming
Stefan Pfeffer
Irmgard Sinning
spellingShingle Klemens Wild
Milan Aleksić
Karine Lapouge
Keven D. Juaire
Dirk Flemming
Stefan Pfeffer
Irmgard Sinning
MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
Nature Communications
author_facet Klemens Wild
Milan Aleksić
Karine Lapouge
Keven D. Juaire
Dirk Flemming
Stefan Pfeffer
Irmgard Sinning
author_sort Klemens Wild
title MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
title_short MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
title_full MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
title_fullStr MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
title_full_unstemmed MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
title_sort metap-like ebp1 occupies the human ribosomal tunnel exit and recruits flexible rrna expansion segments
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-02-01
description The ErbB3 receptor binding protein Ebp1 binds to ribosomes and is linked to translational control. Here, the authors present the cryo-EM structure of human Ebp1 bound to a non-translating 80S ribosome and find that Ebp1 blocks the tunnel exit and recruits the rRNA expansion segment ES27L to the tunnel exit.
url https://doi.org/10.1038/s41467-020-14603-7
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