Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants
Immunogenicity and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (Hib) conjugate vaccine (DTPa-IPV/Hib, Infanrix™-IPV + Hib) was assessed when co-administered with hepatitis B (HBV) vaccine. Seventy healthy infants received...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2011-06-01
|
Series: | Journal of the Formosan Medical Association |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664611600612 |
id |
doaj-4d06d70248ab4154b7c3e4e00a7012e0 |
---|---|
record_format |
Article |
spelling |
doaj-4d06d70248ab4154b7c3e4e00a7012e02020-11-24T22:28:07ZengElsevierJournal of the Formosan Medical Association0929-66462011-06-01110641542210.1016/S0929-6646(11)60061-2Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese InfantsPei-Lan Shao0Chun-Yi Lu1Yu-Chia Hsieh2Hans L Bock3Li-Min Huang4Department of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDivision of Pediatric Infectious Disease, Department of Pediatrics, Chang Gung Children's Hospital, Taipei, TaiwanGlaxoSmithKline Biologicals, Rixensart, BelgiumDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanImmunogenicity and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (Hib) conjugate vaccine (DTPa-IPV/Hib, Infanrix™-IPV + Hib) was assessed when co-administered with hepatitis B (HBV) vaccine. Seventy healthy infants received DTPa-IPV/Hib at 1.5, 3.5, 6 and 15–18 months, and HBV at birth, 1.5, 6 and 15–18 months of age. Serological responses were assessed. Diphtheria, tetanus, Hib and pertussis seroprotection/seropositivity rates were 100% after primary vaccination. Post-primary immune responses to poliovirus could not be evaluated for technical reasons. However, after the booster dose, seroprotection/seropositivity rates, including poliovirus, were 100%. Over 95% were seroprotected against HBV. Post-booster geometric mean antibody concentrations/titers (GMC/GMTs) rose from 14-fold to 45-fold, indicating effective priming against all antigens, including polioviruses. DTPa-IPV/Hib was well tolerated alone or co-administered with HBV. No serious adverse events were considered related to vaccination. Primary and booster vaccination with combined DTPa-IPV/Hib and HBV was immunogenic and well tolerated. Combination vaccines enable vaccine providers to conveniently provide routine pediatric immunizations, with minimal discomfort.http://www.sciencedirect.com/science/article/pii/S0929664611600612 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pei-Lan Shao Chun-Yi Lu Yu-Chia Hsieh Hans L Bock Li-Min Huang |
spellingShingle |
Pei-Lan Shao Chun-Yi Lu Yu-Chia Hsieh Hans L Bock Li-Min Huang Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants Journal of the Formosan Medical Association |
author_facet |
Pei-Lan Shao Chun-Yi Lu Yu-Chia Hsieh Hans L Bock Li-Min Huang |
author_sort |
Pei-Lan Shao |
title |
Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants |
title_short |
Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants |
title_full |
Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants |
title_fullStr |
Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants |
title_full_unstemmed |
Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants |
title_sort |
immunogenicity and reactogenicity of dtpa-ipv/hib vaccine co-administered with hepatitis b vaccine for primary and booster vaccination of taiwanese infants |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2011-06-01 |
description |
Immunogenicity and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (Hib) conjugate vaccine (DTPa-IPV/Hib, Infanrix™-IPV + Hib) was assessed when co-administered with hepatitis B (HBV) vaccine. Seventy healthy infants received DTPa-IPV/Hib at 1.5, 3.5, 6 and 15–18 months, and HBV at birth, 1.5, 6 and 15–18 months of age. Serological responses were assessed. Diphtheria, tetanus, Hib and pertussis seroprotection/seropositivity rates were 100% after primary vaccination. Post-primary immune responses to poliovirus could not be evaluated for technical reasons. However, after the booster dose, seroprotection/seropositivity rates, including poliovirus, were 100%. Over 95% were seroprotected against HBV. Post-booster geometric mean antibody concentrations/titers (GMC/GMTs) rose from 14-fold to 45-fold, indicating effective priming against all antigens, including polioviruses. DTPa-IPV/Hib was well tolerated alone or co-administered with HBV. No serious adverse events were considered related to vaccination. Primary and booster vaccination with combined DTPa-IPV/Hib and HBV was immunogenic and well tolerated. Combination vaccines enable vaccine providers to conveniently provide routine pediatric immunizations, with minimal discomfort. |
url |
http://www.sciencedirect.com/science/article/pii/S0929664611600612 |
work_keys_str_mv |
AT peilanshao immunogenicityandreactogenicityofdtpaipvhibvaccinecoadministeredwithhepatitisbvaccineforprimaryandboostervaccinationoftaiwaneseinfants AT chunyilu immunogenicityandreactogenicityofdtpaipvhibvaccinecoadministeredwithhepatitisbvaccineforprimaryandboostervaccinationoftaiwaneseinfants AT yuchiahsieh immunogenicityandreactogenicityofdtpaipvhibvaccinecoadministeredwithhepatitisbvaccineforprimaryandboostervaccinationoftaiwaneseinfants AT hanslbock immunogenicityandreactogenicityofdtpaipvhibvaccinecoadministeredwithhepatitisbvaccineforprimaryandboostervaccinationoftaiwaneseinfants AT liminhuang immunogenicityandreactogenicityofdtpaipvhibvaccinecoadministeredwithhepatitisbvaccineforprimaryandboostervaccinationoftaiwaneseinfants |
_version_ |
1725747842188836864 |