Effective Delivery of Anti-Cancer Drug Molecules with Shape Transforming Liquid Metal Particles
Liquid metals are being studied intensively because of their potential as a drug delivery system. Eutectic gallium−indium (EGaIn) alloy liquid metals have a low melting point, low toxicity, and excellent tissue permeability. These properties may enable them to be vascular embolic agents th...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-10-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/11/11/1666 |
id |
doaj-4d148540102146ba8583852d069d3fef |
---|---|
record_format |
Article |
spelling |
doaj-4d148540102146ba8583852d069d3fef2020-11-25T01:12:24ZengMDPI AGCancers2072-66942019-10-011111166610.3390/cancers11111666cancers11111666Effective Delivery of Anti-Cancer Drug Molecules with Shape Transforming Liquid Metal ParticlesDasom Kim0Jangsun Hwang1Yonghyun Choi2Yejin Kwon3Jaehee Jang4Semi Yoon5Jonghoon Choi6School of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaLiquid metals are being studied intensively because of their potential as a drug delivery system. Eutectic gallium−indium (EGaIn) alloy liquid metals have a low melting point, low toxicity, and excellent tissue permeability. These properties may enable them to be vascular embolic agents that can be deformed by light or heat. In this study, we developed EGaIn particles that can deliver anticancer drugs to tumor cells in vitro and change their shapes in response to external stimuli. These particles were prepared by sonicating a solution containing EGaIn and amphiphilic lipids. The liquid metal (LM)/amphiphilic lipid (DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholin) particles formed a vehicle for doxorubicin, an anticancer drug, which was released (up to 50%) when the shape of the particles was deformed by light or heat treatment. LM/DSPC particles are non-toxic and LM/DSPC/doxorubicin particles have anticancer effects (resulting in a cell viability of less than 50%). LM/DSPC/doxorubicin particles were also able to mimic blood vessel embolisms by modifying their shape using precisely controlled light and heat in engineered microchannels. The purpose of this study was to examine the potential of EGaIn materials to treat tumor tissues that cannot be removed by surgery.https://www.mdpi.com/2072-6694/11/11/1666liquid metalegainphotothermaldrug delivery systemvascular embolismdoxorubicin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dasom Kim Jangsun Hwang Yonghyun Choi Yejin Kwon Jaehee Jang Semi Yoon Jonghoon Choi |
spellingShingle |
Dasom Kim Jangsun Hwang Yonghyun Choi Yejin Kwon Jaehee Jang Semi Yoon Jonghoon Choi Effective Delivery of Anti-Cancer Drug Molecules with Shape Transforming Liquid Metal Particles Cancers liquid metal egain photothermal drug delivery system vascular embolism doxorubicin |
author_facet |
Dasom Kim Jangsun Hwang Yonghyun Choi Yejin Kwon Jaehee Jang Semi Yoon Jonghoon Choi |
author_sort |
Dasom Kim |
title |
Effective Delivery of Anti-Cancer Drug Molecules with Shape Transforming Liquid Metal Particles |
title_short |
Effective Delivery of Anti-Cancer Drug Molecules with Shape Transforming Liquid Metal Particles |
title_full |
Effective Delivery of Anti-Cancer Drug Molecules with Shape Transforming Liquid Metal Particles |
title_fullStr |
Effective Delivery of Anti-Cancer Drug Molecules with Shape Transforming Liquid Metal Particles |
title_full_unstemmed |
Effective Delivery of Anti-Cancer Drug Molecules with Shape Transforming Liquid Metal Particles |
title_sort |
effective delivery of anti-cancer drug molecules with shape transforming liquid metal particles |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2019-10-01 |
description |
Liquid metals are being studied intensively because of their potential as a drug delivery system. Eutectic gallium−indium (EGaIn) alloy liquid metals have a low melting point, low toxicity, and excellent tissue permeability. These properties may enable them to be vascular embolic agents that can be deformed by light or heat. In this study, we developed EGaIn particles that can deliver anticancer drugs to tumor cells in vitro and change their shapes in response to external stimuli. These particles were prepared by sonicating a solution containing EGaIn and amphiphilic lipids. The liquid metal (LM)/amphiphilic lipid (DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholin) particles formed a vehicle for doxorubicin, an anticancer drug, which was released (up to 50%) when the shape of the particles was deformed by light or heat treatment. LM/DSPC particles are non-toxic and LM/DSPC/doxorubicin particles have anticancer effects (resulting in a cell viability of less than 50%). LM/DSPC/doxorubicin particles were also able to mimic blood vessel embolisms by modifying their shape using precisely controlled light and heat in engineered microchannels. The purpose of this study was to examine the potential of EGaIn materials to treat tumor tissues that cannot be removed by surgery. |
topic |
liquid metal egain photothermal drug delivery system vascular embolism doxorubicin |
url |
https://www.mdpi.com/2072-6694/11/11/1666 |
work_keys_str_mv |
AT dasomkim effectivedeliveryofanticancerdrugmoleculeswithshapetransformingliquidmetalparticles AT jangsunhwang effectivedeliveryofanticancerdrugmoleculeswithshapetransformingliquidmetalparticles AT yonghyunchoi effectivedeliveryofanticancerdrugmoleculeswithshapetransformingliquidmetalparticles AT yejinkwon effectivedeliveryofanticancerdrugmoleculeswithshapetransformingliquidmetalparticles AT jaeheejang effectivedeliveryofanticancerdrugmoleculeswithshapetransformingliquidmetalparticles AT semiyoon effectivedeliveryofanticancerdrugmoleculeswithshapetransformingliquidmetalparticles AT jonghoonchoi effectivedeliveryofanticancerdrugmoleculeswithshapetransformingliquidmetalparticles |
_version_ |
1725166499274948608 |