Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia
While cancer treatment has improved dramatically, it has also encountered many critical challenges, such as disease recurrence, metastasis, and drug resistance, making new drugs with novel mechanisms an urgent clinical need. The term “drug repositioning,” also known as old drugs for new uses, has em...
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doaj-4d18571a52c34494b5df8a75b78847592020-11-25T03:31:01ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-07-01810.3389/fcell.2020.00565548912Repositioning Lidocaine as an Anticancer Drug: The Role Beyond AnesthesiaDaipeng Zhou0Lei Wang1Qingbin Cui2Ryma Iftikhar3Yanfei Xia4Peng Xu5Department of Anesthesiology, Pinghu First People’s Hospital, Jiaxing, ChinaDepartment of Anesthesiology, Pinghu First People’s Hospital, Jiaxing, ChinaCollege of Pharmacy and Health Sciences, St. John’s University, Queens, NY, United StatesCollege of Pharmacy and Health Sciences, St. John’s University, Queens, NY, United StatesDepartment of Anesthesiology, Zhejiang Hospital, Hangzhou, ChinaDepartment of Anesthesiology, Zhejiang Hospital, Hangzhou, ChinaWhile cancer treatment has improved dramatically, it has also encountered many critical challenges, such as disease recurrence, metastasis, and drug resistance, making new drugs with novel mechanisms an urgent clinical need. The term “drug repositioning,” also known as old drugs for new uses, has emerged as one practical strategy to develop new anticancer drugs. Anesthetics have been widely used in surgical procedures to reduce the excruciating pain. Lidocaine, one of the most-used local anesthetics in clinical settings, has been found to show multi-activities, including potential in cancer treatment. Growing evidence shows that lidocaine may not only work as a chemosensitizer that sensitizes other conventional chemotherapeutics to certain resistant cancer cells, but also could suppress cancer cells growth by single use at different doses or concentrations. Lidocaine could suppress cancer cell growth in vitro and in vivo via multiple mechanisms, such as regulating epigenetic changes and promoting pro-apoptosis pathways, as well as regulating ABC transporters, metastasis, and angiogenesis, etc., providing valuable information for its further application in cancer treatment and for new drug discovery. In addition, lidocaine is now under clinical trials to treat certain types of cancer. In the current review, we summarize the research and analyze the underlying mechanisms, and address key issues in this area.https://www.frontiersin.org/article/10.3389/fcell.2020.00565/fulldrug repositioninglidocainechemosensitizeranticancermechanisms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daipeng Zhou Lei Wang Qingbin Cui Ryma Iftikhar Yanfei Xia Peng Xu |
spellingShingle |
Daipeng Zhou Lei Wang Qingbin Cui Ryma Iftikhar Yanfei Xia Peng Xu Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia Frontiers in Cell and Developmental Biology drug repositioning lidocaine chemosensitizer anticancer mechanisms |
author_facet |
Daipeng Zhou Lei Wang Qingbin Cui Ryma Iftikhar Yanfei Xia Peng Xu |
author_sort |
Daipeng Zhou |
title |
Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia |
title_short |
Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia |
title_full |
Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia |
title_fullStr |
Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia |
title_full_unstemmed |
Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia |
title_sort |
repositioning lidocaine as an anticancer drug: the role beyond anesthesia |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-07-01 |
description |
While cancer treatment has improved dramatically, it has also encountered many critical challenges, such as disease recurrence, metastasis, and drug resistance, making new drugs with novel mechanisms an urgent clinical need. The term “drug repositioning,” also known as old drugs for new uses, has emerged as one practical strategy to develop new anticancer drugs. Anesthetics have been widely used in surgical procedures to reduce the excruciating pain. Lidocaine, one of the most-used local anesthetics in clinical settings, has been found to show multi-activities, including potential in cancer treatment. Growing evidence shows that lidocaine may not only work as a chemosensitizer that sensitizes other conventional chemotherapeutics to certain resistant cancer cells, but also could suppress cancer cells growth by single use at different doses or concentrations. Lidocaine could suppress cancer cell growth in vitro and in vivo via multiple mechanisms, such as regulating epigenetic changes and promoting pro-apoptosis pathways, as well as regulating ABC transporters, metastasis, and angiogenesis, etc., providing valuable information for its further application in cancer treatment and for new drug discovery. In addition, lidocaine is now under clinical trials to treat certain types of cancer. In the current review, we summarize the research and analyze the underlying mechanisms, and address key issues in this area. |
topic |
drug repositioning lidocaine chemosensitizer anticancer mechanisms |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00565/full |
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