Searching for Peptide Inhibitors of T Regulatory Cell Activity by Targeting Specific Domains of FOXP3 Transcription Factor

Searching for Peptide Inhibitors of T Regulatory Cell Activity by Targeting Specific Domains of FOXP3 Transcription Factor

(1) Background: The ability of cancer cells to evade the immune system is due in part to their capacity to induce and recruit T regulatory cells (Tregs) to the tumor microenvironment. Strategies proposed to improve antitumor immunity by depleting Tregs generally lack specificity and raise the possib...

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Bibliographic Details
Main Authors: Teresa Lozano, Noelia Casares, Celia Martín-Otal, Blanca Anega, Marta Gorraiz, Jonathan Parker, Marta Ruiz, Virginia Belsúe, Antonio Pineda-Lucena, Julen Oyarzabal, Juan José José Lasarte
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomedicines
Subjects:
T regulatory cells
Foxp3 transcription factor
immunotherapy of cancer
synthetic peptides
inhibition of protein–protein interaction
Online Access:https://www.mdpi.com/2227-9059/9/2/197

Internet

https://www.mdpi.com/2227-9059/9/2/197

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