GWIDD: a comprehensive resource for genome-wide structural modeling of protein-protein interactions

• Main Authors: Kundrotas Petras J, Zhu Zhengwei, Vakser Ilya A
• Format: Article
• Language: English
• Published: BMC 2012-07-01
• Series: Human Genomics
• Subjects: Protein-protein interactions; Structural modeling; Protein docking; Structural genomics; Interactome
• Online Access: http://www.humgenomics.com/content/6/1/7

<p>Abstract</p> <p>Protein-protein interactions are a key component of life processes. The knowledge of the three-dimensional structure of these interactions is important for understanding protein function. Genome-Wide Docking Database (<url>http://gwidd.bioinformatics.ku.edu</url>) offers an extensive source of data for structural studies of protein-protein complexes on genome scale. The current release of the database combines the available experimental data on the structure and characteristics of protein interactions with structural modeling of protein complexes for 771 organisms spanned over the entire universe of life from viruses to humans. The interactions are stored in a relational database with user-friendly interface that includes various search options. The search results can be interactively previewed; the structures, downloaded, along with the interaction characteristics.</p>