Resistance of uropathogens to antibacterial agents: Emerging threats, trends and treatments

• Main Authors: Gianpaolo Perletti, Vittorio Magri, Tommaso Cai, Konstantinos Stamatiou, Alberto Trinchieri, Emanuele Montanari
• Format: Article
• Language: English
• Published: PAGEPress Publications 2018-06-01
• Series: Archivio Italiano di Urologia e Andrologia
• Subjects: Urinary tract infections; Resistance; Antibacterial agents; Antibiotics; Carbapenemase; Carbapenem resistance
• Online Access: https://www.pagepressjournals.org/index.php/aiua/article/view/7499

Urinary tract infections are among the most common infectious diseases in humans. Today, resistance to nearly all antimicrobial classes is dramatically growing, and extremely drug-resistant or even pan-drug resistant pathogens are increasingly isolated around the world. It is foreseen that in the next decades the world will be facing a major medical emergency generated by the rapid spread of pathogens carrying resistance determinants of unprecedented power. Carbapenemase-producing Enterobacteriaceae, multidrug- resistant Enterococci and fluoroquinolone resistance determinants in both Gram-negative and Gram-positive uropathogens are among the greatest emergencies. In this article, the major emerging threats of particular interest to urologists are reviewed, worldwide resistance trends are illustrated, and novel and older – but still active – recommended drugs are summarized.