Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
The endocytic adaptor protein complex AP-2 is mostly known for its role in endocytosis and in synaptic vesicle reformation. Here the authors show that AP-2 also mediates retrograde transport of TrkB-containing autophagosomes in neurons; this process promotes neuronal complexity and prevents the dege...
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Bibliographic Details
Main Authors: |
Natalia L. Kononenko,
Gala A. Claßen,
Marijn Kuijpers,
Dmytro Puchkov,
Tanja Maritzen,
Aleksandra Tempes,
Anna R. Malik,
Agnieszka Skalecka,
Sujoy Bera,
Jacek Jaworski,
Volker Haucke |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-04-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms14819
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