Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration

The endocytic adaptor protein complex AP-2 is mostly known for its role in endocytosis and in synaptic vesicle reformation. Here the authors show that AP-2 also mediates retrograde transport of TrkB-containing autophagosomes in neurons; this process promotes neuronal complexity and prevents the dege...

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Main Authors:	Natalia L. Kononenko, Gala A. Claßen, Marijn Kuijpers, Dmytro Puchkov, Tanja Maritzen, Aleksandra Tempes, Anna R. Malik, Agnieszka Skalecka, Sujoy Bera, Jacek Jaworski, Volker Haucke
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14819

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spelling	doaj-4d27649c1b8945efb76664268ba42b422021-05-11T07:15:37ZengNature Publishing GroupNature Communications2041-17232017-04-018111610.1038/ncomms14819Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegenerationNatalia L. Kononenko0Gala A. Claßen1Marijn Kuijpers2Dmytro Puchkov3Tanja Maritzen4Aleksandra Tempes5Anna R. Malik6Agnieszka Skalecka7Sujoy Bera8Jacek Jaworski9Volker Haucke10Leibniz-Institut für Molekulare PharmakologieLeibniz-Institut für Molekulare PharmakologieLeibniz-Institut für Molekulare PharmakologieLeibniz-Institut für Molekulare PharmakologieLeibniz-Institut für Molekulare PharmakologieLaboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell BiologyLaboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell BiologyLaboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell BiologyCECAD Research Center, University of CologneLaboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell BiologyLeibniz-Institut für Molekulare PharmakologieThe endocytic adaptor protein complex AP-2 is mostly known for its role in endocytosis and in synaptic vesicle reformation. Here the authors show that AP-2 also mediates retrograde transport of TrkB-containing autophagosomes in neurons; this process promotes neuronal complexity and prevents the degeneration of cortical and thalamic neurons.https://doi.org/10.1038/ncomms14819
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Natalia L. Kononenko Gala A. Claßen Marijn Kuijpers Dmytro Puchkov Tanja Maritzen Aleksandra Tempes Anna R. Malik Agnieszka Skalecka Sujoy Bera Jacek Jaworski Volker Haucke
spellingShingle	Natalia L. Kononenko Gala A. Claßen Marijn Kuijpers Dmytro Puchkov Tanja Maritzen Aleksandra Tempes Anna R. Malik Agnieszka Skalecka Sujoy Bera Jacek Jaworski Volker Haucke Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration Nature Communications
author_facet	Natalia L. Kononenko Gala A. Claßen Marijn Kuijpers Dmytro Puchkov Tanja Maritzen Aleksandra Tempes Anna R. Malik Agnieszka Skalecka Sujoy Bera Jacek Jaworski Volker Haucke
author_sort	Natalia L. Kononenko
title	Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
title_short	Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
title_full	Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
title_fullStr	Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
title_full_unstemmed	Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
title_sort	retrograde transport of trkb-containing autophagosomes via the adaptor ap-2 mediates neuronal complexity and prevents neurodegeneration
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-04-01
description	The endocytic adaptor protein complex AP-2 is mostly known for its role in endocytosis and in synaptic vesicle reformation. Here the authors show that AP-2 also mediates retrograde transport of TrkB-containing autophagosomes in neurons; this process promotes neuronal complexity and prevents the degeneration of cortical and thalamic neurons.
url	https://doi.org/10.1038/ncomms14819
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Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration

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