Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
The endocytic adaptor protein complex AP-2 is mostly known for its role in endocytosis and in synaptic vesicle reformation. Here the authors show that AP-2 also mediates retrograde transport of TrkB-containing autophagosomes in neurons; this process promotes neuronal complexity and prevents the dege...
Main Authors: | Natalia L. Kononenko, Gala A. Claßen, Marijn Kuijpers, Dmytro Puchkov, Tanja Maritzen, Aleksandra Tempes, Anna R. Malik, Agnieszka Skalecka, Sujoy Bera, Jacek Jaworski, Volker Haucke |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-04-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms14819 |
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