Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
Allergen-specific immunotherapy is used to treat patients affected by acute immunoglobulin E (IgE) responses, but the function mechanism is unclear. Here the authors show that the administration of two cat allergen-specific IgGs reduces allergic responses in mouse models and helps ameliorate clinica...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03636-8 |
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doaj-4d30f5e885654cfb894aa83d96ba22762021-05-11T10:24:33ZengNature Publishing GroupNature Communications2041-17232018-04-019111510.1038/s41467-018-03636-8Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagementJ. M. Orengo0A. R. Radin1V. Kamat2A. Badithe3L. H. Ben4B. L. Bennett5S. Zhong6D. Birchard7A. Limnander8A. Rafique9J. Bautista10A. Kostic11D. Newell12X. Duan13M. C. Franklin14W. Olson15T. Huang16N. A. Gandhi17L. Lipsich18N. Stahl19N. J. Papadopoulos20A. J. Murphy21G. D. Yancopoulos22Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Regeneron Pharmaceuticals Inc.Allergen-specific immunotherapy is used to treat patients affected by acute immunoglobulin E (IgE) responses, but the function mechanism is unclear. Here the authors show that the administration of two cat allergen-specific IgGs reduces allergic responses in mouse models and helps ameliorate clinical symptoms in a phase 1b clinical trial.https://doi.org/10.1038/s41467-018-03636-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
J. M. Orengo A. R. Radin V. Kamat A. Badithe L. H. Ben B. L. Bennett S. Zhong D. Birchard A. Limnander A. Rafique J. Bautista A. Kostic D. Newell X. Duan M. C. Franklin W. Olson T. Huang N. A. Gandhi L. Lipsich N. Stahl N. J. Papadopoulos A. J. Murphy G. D. Yancopoulos |
| spellingShingle |
J. M. Orengo A. R. Radin V. Kamat A. Badithe L. H. Ben B. L. Bennett S. Zhong D. Birchard A. Limnander A. Rafique J. Bautista A. Kostic D. Newell X. Duan M. C. Franklin W. Olson T. Huang N. A. Gandhi L. Lipsich N. Stahl N. J. Papadopoulos A. J. Murphy G. D. Yancopoulos Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement Nature Communications |
| author_facet |
J. M. Orengo A. R. Radin V. Kamat A. Badithe L. H. Ben B. L. Bennett S. Zhong D. Birchard A. Limnander A. Rafique J. Bautista A. Kostic D. Newell X. Duan M. C. Franklin W. Olson T. Huang N. A. Gandhi L. Lipsich N. Stahl N. J. Papadopoulos A. J. Murphy G. D. Yancopoulos |
| author_sort |
J. M. Orengo |
| title |
Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement |
| title_short |
Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement |
| title_full |
Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement |
| title_fullStr |
Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement |
| title_full_unstemmed |
Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement |
| title_sort |
treating cat allergy with monoclonal igg antibodies that bind allergen and prevent ige engagement |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-04-01 |
| description |
Allergen-specific immunotherapy is used to treat patients affected by acute immunoglobulin E (IgE) responses, but the function mechanism is unclear. Here the authors show that the administration of two cat allergen-specific IgGs reduces allergic responses in mouse models and helps ameliorate clinical symptoms in a phase 1b clinical trial. |
| url |
https://doi.org/10.1038/s41467-018-03636-8 |
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