TRPs in Pain Sensation

According to the International Association for the Study of Pain (IASP) pain is characterized as an “unpleasant sensory and emotional experience associated with actual or potential tissue damage”. The TRP super-family, compressing up to 28 isoforms in mammals, mediates a myriad of physiological and...

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Main Authors: Isaac Jardín, José J. López, Raquel Diez, José Sánchez-Collado, Carlos Cantonero, Letizia Albarrán, Geoffrey E. Woodard, Pedro C. Redondo, Ginés M. Salido, Tarik Smani, Juan A. Rosado
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00392/full
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spelling doaj-4d32a674e4e14723a9a41d53073307272020-11-24T23:04:31ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-06-01810.3389/fphys.2017.00392276145TRPs in Pain SensationIsaac Jardín0José J. López1Raquel Diez2José Sánchez-Collado3Carlos Cantonero4Letizia Albarrán5Geoffrey E. Woodard6Pedro C. Redondo7Ginés M. Salido8Tarik Smani9Juan A. Rosado10Cell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainDepartment of Surgery, Uniformed Services University of the Health SciencesBethesda, MD, United StatesCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainDepartment of Medical Physiology and Biophysics, Institute of Biomedicine of Sevilla, University of SevilleSevilla, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainAccording to the International Association for the Study of Pain (IASP) pain is characterized as an “unpleasant sensory and emotional experience associated with actual or potential tissue damage”. The TRP super-family, compressing up to 28 isoforms in mammals, mediates a myriad of physiological and pathophysiological processes, pain among them. TRP channel might be constituted by similar or different TRP subunits, which will result in the formation of homomeric or heteromeric channels with distinct properties and functions. In this review we will discuss about the function of TRPs in pain, focusing on TRP channles that participate in the transduction of noxious sensation, especially TRPV1 and TRPA1, their expression in nociceptors and their sensitivity to a large number of physical and chemical stimuli.http://journal.frontiersin.org/article/10.3389/fphys.2017.00392/fullcalcium entryTRPsTRPA1TRPV1noxious sensation
collection DOAJ
language English
format Article
sources DOAJ
author Isaac Jardín
José J. López
Raquel Diez
José Sánchez-Collado
Carlos Cantonero
Letizia Albarrán
Geoffrey E. Woodard
Pedro C. Redondo
Ginés M. Salido
Tarik Smani
Juan A. Rosado
spellingShingle Isaac Jardín
José J. López
Raquel Diez
José Sánchez-Collado
Carlos Cantonero
Letizia Albarrán
Geoffrey E. Woodard
Pedro C. Redondo
Ginés M. Salido
Tarik Smani
Juan A. Rosado
TRPs in Pain Sensation
Frontiers in Physiology
calcium entry
TRPs
TRPA1
TRPV1
noxious sensation
author_facet Isaac Jardín
José J. López
Raquel Diez
José Sánchez-Collado
Carlos Cantonero
Letizia Albarrán
Geoffrey E. Woodard
Pedro C. Redondo
Ginés M. Salido
Tarik Smani
Juan A. Rosado
author_sort Isaac Jardín
title TRPs in Pain Sensation
title_short TRPs in Pain Sensation
title_full TRPs in Pain Sensation
title_fullStr TRPs in Pain Sensation
title_full_unstemmed TRPs in Pain Sensation
title_sort trps in pain sensation
publisher Frontiers Media S.A.
series Frontiers in Physiology
issn 1664-042X
publishDate 2017-06-01
description According to the International Association for the Study of Pain (IASP) pain is characterized as an “unpleasant sensory and emotional experience associated with actual or potential tissue damage”. The TRP super-family, compressing up to 28 isoforms in mammals, mediates a myriad of physiological and pathophysiological processes, pain among them. TRP channel might be constituted by similar or different TRP subunits, which will result in the formation of homomeric or heteromeric channels with distinct properties and functions. In this review we will discuss about the function of TRPs in pain, focusing on TRP channles that participate in the transduction of noxious sensation, especially TRPV1 and TRPA1, their expression in nociceptors and their sensitivity to a large number of physical and chemical stimuli.
topic calcium entry
TRPs
TRPA1
TRPV1
noxious sensation
url http://journal.frontiersin.org/article/10.3389/fphys.2017.00392/full
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