TRPs in Pain Sensation
According to the International Association for the Study of Pain (IASP) pain is characterized as an “unpleasant sensory and emotional experience associated with actual or potential tissue damage”. The TRP super-family, compressing up to 28 isoforms in mammals, mediates a myriad of physiological and...
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doaj-4d32a674e4e14723a9a41d53073307272020-11-24T23:04:31ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-06-01810.3389/fphys.2017.00392276145TRPs in Pain SensationIsaac Jardín0José J. López1Raquel Diez2José Sánchez-Collado3Carlos Cantonero4Letizia Albarrán5Geoffrey E. Woodard6Pedro C. Redondo7Ginés M. Salido8Tarik Smani9Juan A. Rosado10Cell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainDepartment of Surgery, Uniformed Services University of the Health SciencesBethesda, MD, United StatesCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainDepartment of Medical Physiology and Biophysics, Institute of Biomedicine of Sevilla, University of SevilleSevilla, SpainCell Physiology Research Group, Department of Physiology, University of ExtremaduraCáceres, SpainAccording to the International Association for the Study of Pain (IASP) pain is characterized as an “unpleasant sensory and emotional experience associated with actual or potential tissue damage”. The TRP super-family, compressing up to 28 isoforms in mammals, mediates a myriad of physiological and pathophysiological processes, pain among them. TRP channel might be constituted by similar or different TRP subunits, which will result in the formation of homomeric or heteromeric channels with distinct properties and functions. In this review we will discuss about the function of TRPs in pain, focusing on TRP channles that participate in the transduction of noxious sensation, especially TRPV1 and TRPA1, their expression in nociceptors and their sensitivity to a large number of physical and chemical stimuli.http://journal.frontiersin.org/article/10.3389/fphys.2017.00392/fullcalcium entryTRPsTRPA1TRPV1noxious sensation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isaac Jardín José J. López Raquel Diez José Sánchez-Collado Carlos Cantonero Letizia Albarrán Geoffrey E. Woodard Pedro C. Redondo Ginés M. Salido Tarik Smani Juan A. Rosado |
spellingShingle |
Isaac Jardín José J. López Raquel Diez José Sánchez-Collado Carlos Cantonero Letizia Albarrán Geoffrey E. Woodard Pedro C. Redondo Ginés M. Salido Tarik Smani Juan A. Rosado TRPs in Pain Sensation Frontiers in Physiology calcium entry TRPs TRPA1 TRPV1 noxious sensation |
author_facet |
Isaac Jardín José J. López Raquel Diez José Sánchez-Collado Carlos Cantonero Letizia Albarrán Geoffrey E. Woodard Pedro C. Redondo Ginés M. Salido Tarik Smani Juan A. Rosado |
author_sort |
Isaac Jardín |
title |
TRPs in Pain Sensation |
title_short |
TRPs in Pain Sensation |
title_full |
TRPs in Pain Sensation |
title_fullStr |
TRPs in Pain Sensation |
title_full_unstemmed |
TRPs in Pain Sensation |
title_sort |
trps in pain sensation |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2017-06-01 |
description |
According to the International Association for the Study of Pain (IASP) pain is characterized as an “unpleasant sensory and emotional experience associated with actual or potential tissue damage”. The TRP super-family, compressing up to 28 isoforms in mammals, mediates a myriad of physiological and pathophysiological processes, pain among them. TRP channel might be constituted by similar or different TRP subunits, which will result in the formation of homomeric or heteromeric channels with distinct properties and functions. In this review we will discuss about the function of TRPs in pain, focusing on TRP channles that participate in the transduction of noxious sensation, especially TRPV1 and TRPA1, their expression in nociceptors and their sensitivity to a large number of physical and chemical stimuli. |
topic |
calcium entry TRPs TRPA1 TRPV1 noxious sensation |
url |
http://journal.frontiersin.org/article/10.3389/fphys.2017.00392/full |
work_keys_str_mv |
AT isaacjardin trpsinpainsensation AT josejlopez trpsinpainsensation AT raqueldiez trpsinpainsensation AT josesanchezcollado trpsinpainsensation AT carloscantonero trpsinpainsensation AT letiziaalbarran trpsinpainsensation AT geoffreyewoodard trpsinpainsensation AT pedrocredondo trpsinpainsensation AT ginesmsalido trpsinpainsensation AT tariksmani trpsinpainsensation AT juanarosado trpsinpainsensation |
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