Curcumin potentiates rhabdomyosarcoma radiosensitivity by suppressing NF-κB activity.

Curcumin potentiates rhabdomyosarcoma radiosensitivity by suppressing NF-κB activity.

Ionizing radiation (IR) is an essential component of therapy for alveolar rhabdomyosarcoma. Nuclear factor-kappaB (NF-κΒ) transcription factors are upregulated by IR and have been implicated in radioresistance. We evaluated the ability of curcumin, a putative NF-κΒ inhibitor, and cells expressing ge...

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Bibliographic Details
Main Authors: W Shannon Orr, Jason W Denbo, Karim R Saab, Catherine Y Ng, Jianrong Wu, Kui Li, Jo Meagan Garner, Christopher L Morton, Ziyun Du, Lawrence M Pfeffer, Andrew M Davidoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3567084?pdf=render

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http://europepmc.org/articles/PMC3567084?pdf=render

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