Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
Abstract Background The aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE). Methods A systematic review of the literature was performed using two databases (MEDLINE and EMBASE) through April 20...
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doaj-4d416ab8b5274b79b13594975bae34782020-11-24T21:47:11ZengBMCArthritis Research & Therapy1478-63622017-10-0119111210.1186/s13075-017-1442-6Predictive biological markers of systemic lupus erythematosus flares: a systematic literature reviewNoémie Gensous0Aurélie Marti1Thomas Barnetche2Patrick Blanco3Estibaliz Lazaro4Julien Seneschal5Marie-Elise Truchetet6Pierre Duffau7Christophe Richez8on behalf of the FHU ACRONIMImmunoConcept, UMR CNRS 5164, Université de BordeauxDepartment of Dermatology, Saint-Andre HospitalDepartment of Rheumatology, Pellegrin HospitalImmunoConcept, UMR CNRS 5164, Université de BordeauxImmunoConcept, UMR CNRS 5164, Université de BordeauxDepartment of Dermatology, Saint-Andre HospitalImmunoConcept, UMR CNRS 5164, Université de BordeauxImmunoConcept, UMR CNRS 5164, Université de BordeauxImmunoConcept, UMR CNRS 5164, Université de BordeauxAbstract Background The aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE). Methods A systematic review of the literature was performed using two databases (MEDLINE and EMBASE) through April 2015 and congress abstracts from the American College of Rheumatology and the European League Against Rheumatism were reviewed from 2010 to 2014. Two independent reviewers screened titles and abstracts and analysed selected papers in detail, using a specific questionnaire. Reports addressing the relationships between one or more defined biological test(s) and the occurrence of disease exacerbation were included in the systematic review. Results From all of the databases, 4668 records were retrieved, of which 69 studies or congress abstracts were selected for the systematic review. The performance of seven types of biomarkers performed routinely in clinical practice and nine types of novel biological markers was evaluated. Despite some encouraging results for anti-double-stranded DNA antibodies, anti-C1q antibodies, B-lymphocyte stimulator and tumour necrosis factor-like weak inducer of apoptosis, none of the biomarkers stood out from the others as a potential gold standard for flare prediction. The results were heterogeneous, and a lack of standardized data prevented us from identifying a powerful biomarker. Conclusions No powerful conclusions could be drawn from this systematic review due to a lack of standardized data. Efforts should be undertaken to optimize future research on potential SLE biomarkers to develop validated candidates. Thus, we propose a standardized pattern for future studies.http://link.springer.com/article/10.1186/s13075-017-1442-6Systemic lupus erythematosusBiomarkerFlareExacerbationSystematic review |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Noémie Gensous Aurélie Marti Thomas Barnetche Patrick Blanco Estibaliz Lazaro Julien Seneschal Marie-Elise Truchetet Pierre Duffau Christophe Richez on behalf of the FHU ACRONIM |
spellingShingle |
Noémie Gensous Aurélie Marti Thomas Barnetche Patrick Blanco Estibaliz Lazaro Julien Seneschal Marie-Elise Truchetet Pierre Duffau Christophe Richez on behalf of the FHU ACRONIM Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review Arthritis Research & Therapy Systemic lupus erythematosus Biomarker Flare Exacerbation Systematic review |
author_facet |
Noémie Gensous Aurélie Marti Thomas Barnetche Patrick Blanco Estibaliz Lazaro Julien Seneschal Marie-Elise Truchetet Pierre Duffau Christophe Richez on behalf of the FHU ACRONIM |
author_sort |
Noémie Gensous |
title |
Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review |
title_short |
Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review |
title_full |
Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review |
title_fullStr |
Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review |
title_full_unstemmed |
Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review |
title_sort |
predictive biological markers of systemic lupus erythematosus flares: a systematic literature review |
publisher |
BMC |
series |
Arthritis Research & Therapy |
issn |
1478-6362 |
publishDate |
2017-10-01 |
description |
Abstract Background The aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE). Methods A systematic review of the literature was performed using two databases (MEDLINE and EMBASE) through April 2015 and congress abstracts from the American College of Rheumatology and the European League Against Rheumatism were reviewed from 2010 to 2014. Two independent reviewers screened titles and abstracts and analysed selected papers in detail, using a specific questionnaire. Reports addressing the relationships between one or more defined biological test(s) and the occurrence of disease exacerbation were included in the systematic review. Results From all of the databases, 4668 records were retrieved, of which 69 studies or congress abstracts were selected for the systematic review. The performance of seven types of biomarkers performed routinely in clinical practice and nine types of novel biological markers was evaluated. Despite some encouraging results for anti-double-stranded DNA antibodies, anti-C1q antibodies, B-lymphocyte stimulator and tumour necrosis factor-like weak inducer of apoptosis, none of the biomarkers stood out from the others as a potential gold standard for flare prediction. The results were heterogeneous, and a lack of standardized data prevented us from identifying a powerful biomarker. Conclusions No powerful conclusions could be drawn from this systematic review due to a lack of standardized data. Efforts should be undertaken to optimize future research on potential SLE biomarkers to develop validated candidates. Thus, we propose a standardized pattern for future studies. |
topic |
Systemic lupus erythematosus Biomarker Flare Exacerbation Systematic review |
url |
http://link.springer.com/article/10.1186/s13075-017-1442-6 |
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