Vasculitis damage index in Behçet’s disease
Abstract Background Vasculitis damage index (VDI) is a validated damage index for systemic vasculitis, and as Behçet’s disease is considered one of systemic vascular disease we aimed to study the relationship of the vasculitis damage index to clinical manifestations and comorbidity in patients with...
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doaj-4d435cfdaf4741f9abe303430a722d392021-06-13T11:53:14ZengBMCAdvances in Rheumatology2523-31062021-06-016111710.1186/s42358-021-00193-5Vasculitis damage index in Behçet’s diseaseFatema T. Elgengehy0Sherif M. Gamal1Nesreen Sobhy2Ibrahem Siam3Ahmed M. Soliman4Ghada W. Elhady5Tamer A. Gheita6Rheumatology and Rehabilitation Department, Cairo UniversityRheumatology and Rehabilitation Department, Cairo UniversityRheumatology and Rehabilitation Department, Cairo UniversityInternal Medicine Department, National Research CenterDermatology and venereology Department, National Research CenterPublic Health Department, Cairo UniversityRheumatology and Rehabilitation Department, Cairo UniversityAbstract Background Vasculitis damage index (VDI) is a validated damage index for systemic vasculitis, and as Behçet’s disease is considered one of systemic vascular disease we aimed to study the relationship of the vasculitis damage index to clinical manifestations and comorbidity in patients with Behçet’s disease (BD) to determine if VDI could be used to assess damage in patients with BD. Methods A total of 109 patients with BD were recruited from the Rheumatology Department (outpatient and inpatient clinic), Cairo University Hospitals. All patients were subjected to full history taking, clinical examination, and routine laboratory investigations. Disease activity was assessed by the BD current activity form, and the VDI was calculated in all patients. The relationship of the VDI to the disease clinical manifestations was studied. Mann–Whitney and Kruskal Wallis tests were used to estimate differences in quantitative variables. Spearman correlation test was used to test for correlation between quantitative variables. Results In the current study, the VDI ranged from 1 to 10, with a mean of 3.5 ± 1.8. It was significantly associated with total thrombosis (P = 0.022); total neurological manifestations (P = 0.000), especially stroke and cranial nerve affection; uveitis (P = 0.005); avascular necrosis (AVN) (P = 0.015); osteoporosis (P = 0.01); impaired vision (P < 0.0001); cataract (P < 0.0001); and diabetes (P = 0.012). Generally, immunosuppressive treatment was significantly associated with VDI (P = 0.039), especially cyclophosphamide (P < 0.0001), biological agent (P = 0.008), chlorambucil (P = 0.003), and anticoagulant (P = 0.02). VDI was also significantly correlated with age (P = 0.033), disease duration (P = 0.029), and duration of eye involvement (P = 0.003). Conclusion VDI is significantly associated with most disease parameters of BD, except for parameters such as mucocutaneous manifestations and uncomplicated venous thrombosis; however, further studies may be needed to establish BD-specific damage index.https://doi.org/10.1186/s42358-021-00193-5Vasculitis damage indexBehçet’s diseaseEgyptian Patients |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fatema T. Elgengehy Sherif M. Gamal Nesreen Sobhy Ibrahem Siam Ahmed M. Soliman Ghada W. Elhady Tamer A. Gheita |
spellingShingle |
Fatema T. Elgengehy Sherif M. Gamal Nesreen Sobhy Ibrahem Siam Ahmed M. Soliman Ghada W. Elhady Tamer A. Gheita Vasculitis damage index in Behçet’s disease Advances in Rheumatology Vasculitis damage index Behçet’s disease Egyptian Patients |
author_facet |
Fatema T. Elgengehy Sherif M. Gamal Nesreen Sobhy Ibrahem Siam Ahmed M. Soliman Ghada W. Elhady Tamer A. Gheita |
author_sort |
Fatema T. Elgengehy |
title |
Vasculitis damage index in Behçet’s disease |
title_short |
Vasculitis damage index in Behçet’s disease |
title_full |
Vasculitis damage index in Behçet’s disease |
title_fullStr |
Vasculitis damage index in Behçet’s disease |
title_full_unstemmed |
Vasculitis damage index in Behçet’s disease |
title_sort |
vasculitis damage index in behçet’s disease |
publisher |
BMC |
series |
Advances in Rheumatology |
issn |
2523-3106 |
publishDate |
2021-06-01 |
description |
Abstract Background Vasculitis damage index (VDI) is a validated damage index for systemic vasculitis, and as Behçet’s disease is considered one of systemic vascular disease we aimed to study the relationship of the vasculitis damage index to clinical manifestations and comorbidity in patients with Behçet’s disease (BD) to determine if VDI could be used to assess damage in patients with BD. Methods A total of 109 patients with BD were recruited from the Rheumatology Department (outpatient and inpatient clinic), Cairo University Hospitals. All patients were subjected to full history taking, clinical examination, and routine laboratory investigations. Disease activity was assessed by the BD current activity form, and the VDI was calculated in all patients. The relationship of the VDI to the disease clinical manifestations was studied. Mann–Whitney and Kruskal Wallis tests were used to estimate differences in quantitative variables. Spearman correlation test was used to test for correlation between quantitative variables. Results In the current study, the VDI ranged from 1 to 10, with a mean of 3.5 ± 1.8. It was significantly associated with total thrombosis (P = 0.022); total neurological manifestations (P = 0.000), especially stroke and cranial nerve affection; uveitis (P = 0.005); avascular necrosis (AVN) (P = 0.015); osteoporosis (P = 0.01); impaired vision (P < 0.0001); cataract (P < 0.0001); and diabetes (P = 0.012). Generally, immunosuppressive treatment was significantly associated with VDI (P = 0.039), especially cyclophosphamide (P < 0.0001), biological agent (P = 0.008), chlorambucil (P = 0.003), and anticoagulant (P = 0.02). VDI was also significantly correlated with age (P = 0.033), disease duration (P = 0.029), and duration of eye involvement (P = 0.003). Conclusion VDI is significantly associated with most disease parameters of BD, except for parameters such as mucocutaneous manifestations and uncomplicated venous thrombosis; however, further studies may be needed to establish BD-specific damage index. |
topic |
Vasculitis damage index Behçet’s disease Egyptian Patients |
url |
https://doi.org/10.1186/s42358-021-00193-5 |
work_keys_str_mv |
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