Adult hepatoblastoma
Adult hepatoblastoma (AHB) is a very rare tumor, having been described 45 cases up to June 2012. In contrast to HB in infancy (IHB), it has poor prognosis. We present the case of a 37-year-old asymptomatic woman who consulted for a large -12 cm diameter- mass involving segments 5 and 6 of the liver,...
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doaj-4d44ca2f89f84a579667623f6af17a1c2020-11-24T23:53:36ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01081054229231S1130-01082013000400009Adult hepatoblastomaJavier A. Cienfuegos0Tania Labiano1Nicolás Pedano2Gabriel N. Zozaya3Pablo Martí-Cruchaga4Ángel Panizo5Fernando Rotellar6Clinica Universidad de NavarraClinica Universidad de NavarraClinica Universidad de NavarraClinica Universidad de NavarraClinica Universidad de NavarraClinica Universidad de NavarraClinica Universidad de NavarraAdult hepatoblastoma (AHB) is a very rare tumor, having been described 45 cases up to June 2012. In contrast to HB in infancy (IHB), it has poor prognosis. We present the case of a 37-year-old asymptomatic woman who consulted for a large -12 cm diameter- mass involving segments 5 and 6 of the liver, and alfa-fetoprotein of 1,556,30 UI/mL. A bisegmentectomy was carried out. The microscopic study confirmed the AHB diagnosis, revealing the presence of epithelial cells forming clusters, trabecular patterns and tubules. The patient died on the 10th postoperative month due to progression disease. The Wnt/β-Catenin signaling pathway mutation has been reported and associated with a poor prognosis in IHB. Due to the AHB poor prognosis, seems reasonable to introduce the therapeutic regimens described in children who have a better outcome.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000400009&lng=en&tlng=enHepatoblastoma adultoVía Wnt/β-Catenina |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Javier A. Cienfuegos Tania Labiano Nicolás Pedano Gabriel N. Zozaya Pablo Martí-Cruchaga Ángel Panizo Fernando Rotellar |
spellingShingle |
Javier A. Cienfuegos Tania Labiano Nicolás Pedano Gabriel N. Zozaya Pablo Martí-Cruchaga Ángel Panizo Fernando Rotellar Adult hepatoblastoma Revista Espanola de Enfermedades Digestivas Hepatoblastoma adulto Vía Wnt/β-Catenina |
author_facet |
Javier A. Cienfuegos Tania Labiano Nicolás Pedano Gabriel N. Zozaya Pablo Martí-Cruchaga Ángel Panizo Fernando Rotellar |
author_sort |
Javier A. Cienfuegos |
title |
Adult hepatoblastoma |
title_short |
Adult hepatoblastoma |
title_full |
Adult hepatoblastoma |
title_fullStr |
Adult hepatoblastoma |
title_full_unstemmed |
Adult hepatoblastoma |
title_sort |
adult hepatoblastoma |
publisher |
Aran Ediciones |
series |
Revista Espanola de Enfermedades Digestivas |
issn |
1130-0108 |
description |
Adult hepatoblastoma (AHB) is a very rare tumor, having been described 45 cases up to June 2012. In contrast to HB in infancy (IHB), it has poor prognosis. We present the case of a 37-year-old asymptomatic woman who consulted for a large -12 cm diameter- mass involving segments 5 and 6 of the liver, and alfa-fetoprotein of 1,556,30 UI/mL. A bisegmentectomy was carried out. The microscopic study confirmed the AHB diagnosis, revealing the presence of epithelial cells forming clusters, trabecular patterns and tubules. The patient died on the 10th postoperative month due to progression disease. The Wnt/β-Catenin signaling pathway mutation has been reported and associated with a poor prognosis in IHB. Due to the AHB poor prognosis, seems reasonable to introduce the therapeutic regimens described in children who have a better outcome. |
topic |
Hepatoblastoma adulto Vía Wnt/β-Catenina |
url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000400009&lng=en&tlng=en |
work_keys_str_mv |
AT javieracienfuegos adulthepatoblastoma AT tanialabiano adulthepatoblastoma AT nicolaspedano adulthepatoblastoma AT gabrielnzozaya adulthepatoblastoma AT pablomarticruchaga adulthepatoblastoma AT angelpanizo adulthepatoblastoma AT fernandorotellar adulthepatoblastoma |
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1725468922536263680 |