Diagnosis for ALK Positive Non-small Cell Lung Cancer

• Main Authors: Qin FENG, Xin YANG, Dongmei LIN
• Format: Article
• Language: zho
• Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2015-02-01
• Series: Chinese Journal of Lung Cancer
• Subjects: Lung neoplasms; Anaplastic lymphoma kinase; Fluorescence in situ hybridization; Immunohistochemistry; Polymerase chain reaction
• Online Access: http://dx.doi.org/10.3779/j.issn.1009-3419.2015.02.02

The anaplastic lymphoma kinase (ALK) gene rearrangement is a driver gene of non-small cell lung cancer (NSCLC). Positive expression of ALK gene rearrangement has been considered a molecular subtype of NSCLC, that there are special pathological characteristics and clinical prognosis. Furthermore, the tyrosine kinase inhibitor has demonstrated high effective in treating ALK positive NSCLC patients. Thus making molecular diagnostic testing for ALK expression is an important step in the process of pathological diagnosis. Currently, many detecting ALK expression assays are available or in development, clinical pathologists focus on how to choose the best method for routine diagnosis of lung cancer. There are many domestic and international authoritative guidelines recommend ALK detecting assays, technological process and relative standard. In the current review, we summarize the diagnostic tests available and the special sample types that could be used to identify patients with ALK-positive NSCLC.