Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease

Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease

Alpha-Synuclein (α-Syn) is a central protein in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders including Parkinson’s disease (PD). Although its role in neurotransmission is well established, the precise role of this protein in disease pathogenesis is still not fully un...

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Bibliographic Details
Main Authors: Valentina Gilmozzi, Giovanna Gentile, Maria Paulina Castelo Rueda, Andrew A. Hicks, Peter P. Pramstaller, Alessandra Zanon, Martin Lévesque, Irene Pichler
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neuroscience
Subjects:
alpha-synuclein
Parkinson’s disease
lipids
cardiolipin
aggregation
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.578993/full

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