Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide
The data presented here detail the changes in size, cellular content, and neuronal density of the developing brain over time with respect to sex in C57Bl/6 mice following neonatal exposure to isoflurane, carbon monoxide, or their combination. Specifically, brain weight- and brain volume-to-body weig...
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doaj-4d64bdb44e324c24a228cb0f9787531d2020-11-25T02:02:29ZengElsevierData in Brief2352-34092017-08-0113550556Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxideLi Wang0Aili Wang1William W. Supplee2Kayla Koffler3Ying Cheng4Zenaide M.N. Quezado5Richard J. Levy6The Sheikh Zayed Institute for Pediatric Surgical Innovation, Division of Pain Medicine, Children׳s National Health System, Children׳s Research Institute, The George Washington University School of Medicine and Health Sciences, United StatesDepartment of Anesthesiology, Columbia University Medical Center, United StatesRutgers New Jersey Medical School, United StatesDepartment of Anesthesiology, Columbia University Medical Center, United StatesCenter for Genetic Medicine Research, Children׳s National Health System, Children׳s Research Institute, The George Washington University School of Medicine and Health Sciences, United StatesThe Sheikh Zayed Institute for Pediatric Surgical Innovation, Division of Pain Medicine, Children׳s National Health System, Children׳s Research Institute, The George Washington University School of Medicine and Health Sciences, United StatesDepartment of Anesthesiology, Columbia University Medical Center, United States; Corresponding author.The data presented here detail the changes in size, cellular content, and neuronal density of the developing brain over time with respect to sex in C57Bl/6 mice following neonatal exposure to isoflurane, carbon monoxide, or their combination. Specifically, brain weight- and brain volume-to-body weight ratios are presented, representative immunoblots of whole brain cell-specific protein content are depicted, and quantification of the number of neurons in the primary somatosensory cortex and CA3 region of the hippocampus are shown. Three discrete postnatal time points are represented: P7 (prior to exposure), P14 (one-week post exposure), and P42-56 (5–7 weeks post exposure). Major findings from the data presented here are reported in the manuscript “Carbon Monoxide Incompletely Prevents Isoflurane-induced Defects in Murine Neurodevelopment'' (Wang et al., in press) [1].http://www.sciencedirect.com/science/article/pii/S235234091730272X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li Wang Aili Wang William W. Supplee Kayla Koffler Ying Cheng Zenaide M.N. Quezado Richard J. Levy |
spellingShingle |
Li Wang Aili Wang William W. Supplee Kayla Koffler Ying Cheng Zenaide M.N. Quezado Richard J. Levy Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide Data in Brief |
author_facet |
Li Wang Aili Wang William W. Supplee Kayla Koffler Ying Cheng Zenaide M.N. Quezado Richard J. Levy |
author_sort |
Li Wang |
title |
Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide |
title_short |
Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide |
title_full |
Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide |
title_fullStr |
Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide |
title_full_unstemmed |
Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide |
title_sort |
data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide |
publisher |
Elsevier |
series |
Data in Brief |
issn |
2352-3409 |
publishDate |
2017-08-01 |
description |
The data presented here detail the changes in size, cellular content, and neuronal density of the developing brain over time with respect to sex in C57Bl/6 mice following neonatal exposure to isoflurane, carbon monoxide, or their combination. Specifically, brain weight- and brain volume-to-body weight ratios are presented, representative immunoblots of whole brain cell-specific protein content are depicted, and quantification of the number of neurons in the primary somatosensory cortex and CA3 region of the hippocampus are shown. Three discrete postnatal time points are represented: P7 (prior to exposure), P14 (one-week post exposure), and P42-56 (5–7 weeks post exposure). Major findings from the data presented here are reported in the manuscript “Carbon Monoxide Incompletely Prevents Isoflurane-induced Defects in Murine Neurodevelopment'' (Wang et al., in press) [1]. |
url |
http://www.sciencedirect.com/science/article/pii/S235234091730272X |
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