A point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19)
Background: Earlier studies have reported high antibiotic use in patients hospitalised for coronavirus disease 2019 (COVID-19), resulting in concerns of increasing antimicrobial resistance with increase antibiotic use in this pandemic. Point prevalence survey (PPS) can be a quick tool to provide ant...
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doaj-4d651ad2e22541e8b636ec1c4b7b34972021-06-09T05:58:09ZengElsevierJournal of Global Antimicrobial Resistance2213-71652021-03-01244547A point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19)Sock Hoon Tan0Tat Ming Ng1Hui Lin Tay2Min Yi Yap3Shi Thong Heng4Audrey Yong Xin Loo5Christine B. Teng6Tau Hong Lee7Department of Pharmacy, Tan Tock Seng Hospital, Singapore, SingaporeDepartment of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore; Corresponding author at: Department of Pharmacy, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore.Department of Pharmacy, Tan Tock Seng Hospital, Singapore, SingaporeDepartment of Pharmacy, Tan Tock Seng Hospital, Singapore, SingaporeDepartment of Pharmacy, Tan Tock Seng Hospital, Singapore, SingaporeDepartment of Pharmacy, Tan Tock Seng Hospital, Singapore, SingaporeDepartment of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, SingaporeDepartment of Infectious Diseases, National Centre for Infectious Diseases, Singapore, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeBackground: Earlier studies have reported high antibiotic use in patients hospitalised for coronavirus disease 2019 (COVID-19), resulting in concerns of increasing antimicrobial resistance with increase antibiotic use in this pandemic. Point prevalence survey (PPS) can be a quick tool to provide antibiotic prescribing information to aid antimicrobial stewardship (AMS) activities. Objectives: To describe antibiotic utilization and evaluate antibiotic appropriateness in COVID-19 patients using PPS. Methods: Adapting Global-PPS on antimicrobial use, the survey was conducted in COVID-19 wards at 2 centres in Singapore on 22 April 2020 at 0800h. Patients on systemic antibiotics were included and evaluated for antibiotic appropriateness. Results: Five hundred and seventy-seven patients were screened. Thirty-six (6.2%) patients were on antibiotics and which were started at median of 7 days (inter-quartile rate (IQR), 4, 11) from symptom onset. Fifty-one antibiotics were prescribed in these patients. Overall, co-amoxiclav (26/51, 51.0%) was the most often prescribed antibiotic. Thirty-one out of 51 (60.8%) antibiotic prescriptions were appropriate. Among 20 inappropriate prescriptions, 18 (90.0%) were initiated in patients with low likelihood of bacterial infections. Antibiotic prescriptions were more appropriate when reviewed by infectious diseases physicians (13/31 [41.9%] versus 2/20 [10.0%], p = 0.015), and if reasons for use were stated in notes (31/31 [100.0%] versus 16/20 [80.0%], p = 0.019). Conclusions: Despite low prevalence of antibiotic use among confirmed and suspected COVID-19 patients at 2 centres in Singapore, there was significant proportion of inappropriate antibiotics use where bacterial infections were unlikely. AMS teams can tailor stewardship strategies using PPS results.http://www.sciencedirect.com/science/article/pii/S2213716520303118CoronavirusCOVID-19AntibioticPoint prevalence surveyStewardship |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sock Hoon Tan Tat Ming Ng Hui Lin Tay Min Yi Yap Shi Thong Heng Audrey Yong Xin Loo Christine B. Teng Tau Hong Lee |
spellingShingle |
Sock Hoon Tan Tat Ming Ng Hui Lin Tay Min Yi Yap Shi Thong Heng Audrey Yong Xin Loo Christine B. Teng Tau Hong Lee A point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19) Journal of Global Antimicrobial Resistance Coronavirus COVID-19 Antibiotic Point prevalence survey Stewardship |
author_facet |
Sock Hoon Tan Tat Ming Ng Hui Lin Tay Min Yi Yap Shi Thong Heng Audrey Yong Xin Loo Christine B. Teng Tau Hong Lee |
author_sort |
Sock Hoon Tan |
title |
A point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19) |
title_short |
A point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19) |
title_full |
A point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19) |
title_fullStr |
A point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19) |
title_full_unstemmed |
A point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19) |
title_sort |
point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (covid-19) |
publisher |
Elsevier |
series |
Journal of Global Antimicrobial Resistance |
issn |
2213-7165 |
publishDate |
2021-03-01 |
description |
Background: Earlier studies have reported high antibiotic use in patients hospitalised for coronavirus disease 2019 (COVID-19), resulting in concerns of increasing antimicrobial resistance with increase antibiotic use in this pandemic. Point prevalence survey (PPS) can be a quick tool to provide antibiotic prescribing information to aid antimicrobial stewardship (AMS) activities. Objectives: To describe antibiotic utilization and evaluate antibiotic appropriateness in COVID-19 patients using PPS. Methods: Adapting Global-PPS on antimicrobial use, the survey was conducted in COVID-19 wards at 2 centres in Singapore on 22 April 2020 at 0800h. Patients on systemic antibiotics were included and evaluated for antibiotic appropriateness. Results: Five hundred and seventy-seven patients were screened. Thirty-six (6.2%) patients were on antibiotics and which were started at median of 7 days (inter-quartile rate (IQR), 4, 11) from symptom onset. Fifty-one antibiotics were prescribed in these patients. Overall, co-amoxiclav (26/51, 51.0%) was the most often prescribed antibiotic. Thirty-one out of 51 (60.8%) antibiotic prescriptions were appropriate. Among 20 inappropriate prescriptions, 18 (90.0%) were initiated in patients with low likelihood of bacterial infections. Antibiotic prescriptions were more appropriate when reviewed by infectious diseases physicians (13/31 [41.9%] versus 2/20 [10.0%], p = 0.015), and if reasons for use were stated in notes (31/31 [100.0%] versus 16/20 [80.0%], p = 0.019). Conclusions: Despite low prevalence of antibiotic use among confirmed and suspected COVID-19 patients at 2 centres in Singapore, there was significant proportion of inappropriate antibiotics use where bacterial infections were unlikely. AMS teams can tailor stewardship strategies using PPS results. |
topic |
Coronavirus COVID-19 Antibiotic Point prevalence survey Stewardship |
url |
http://www.sciencedirect.com/science/article/pii/S2213716520303118 |
work_keys_str_mv |
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