Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H

Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H

Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases. Complement factors are mainly liver-born and present in circulation. Nevertheless, there is a growing body of ev...

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Bibliographic Details
Main Authors: Anne K. Mühlig, Lindsay S. Keir, Jana C. Abt, Hannah S. Heidelbach, Rachel Horton, Gavin I. Welsh, Catherine Meyer-Schwesinger, Christoph Licht, Richard J. Coward, Lars Fester, Moin A. Saleem, Jun Oh
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
complement secretion
proteinuria
glomerulus
kidney
local regulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01833/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01833/full

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