Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome
Abstract Background MicroRNAs (miRNAs) serve as important regulators of inflammatory and immune responses and are implicated in several immune disorders including gouty arthritis. The expression of miR-146a is upregulated in the peripheral blood mononuclear cells of patients with inter-critical gout...
Main Authors: | Quan-Bo Zhang, Yu-Feng Qing, Cong-Cong Yin, Li Zhou, Xian-shuang Liu, Qing-Sheng Mi, Jing-Guo Zhou |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-03-01
|
Series: | Arthritis Research & Therapy |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13075-018-1546-7 |
Similar Items
-
Ricin Toxin Activates the NALP3 Inflammasome
by: Meghan Lindauer, et al.
Published: (2010-06-01) -
MiR-146a Ameliorates Hemoglobin-Induced Microglial Inflammatory Response via TLR4/IRAK1/TRAF6 Associated Pathways
by: Guang-Jie Liu, et al.
Published: (2020-04-01) -
Modulation of NALP3 Inflammasome Genes by Estrogen
by: Chesnokov, Anton P, Mr.
Published: (2011) -
Dexmedetomidine exerts cardioprotective effect through miR-146a-3p targeting IRAK1 and TRAF6 via inhibition of the NF-κB pathway
by: Liang He, et al.
Published: (2021-01-01) -
Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway
by: Zhiyao Wang, et al.
Published: (2018-06-01)