Diabetes in urban Guinea-Bissau; patient characteristics, mortality and prevalence of undiagnosed dysglycemia
Background The burden of diabetes mellitus in Sub-Saharan Africa is growing rapidly, and yet the prevalence and patient characteristics are still largely unknown. Objectives We analyzed clinical and demographic characteristics of Type 2 diabetes (T2DM) patients attending a diabetes clinic in Guinea-...
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doaj-4d888cb39b4b4396bc14e2192a121d9b2021-09-20T13:59:58ZengTaylor & Francis GroupGlobal Health Action1654-98802020-12-0113110.1080/16549716.2020.18021361802136Diabetes in urban Guinea-Bissau; patient characteristics, mortality and prevalence of undiagnosed dysglycemiaStine Byberg0Camilla Bundesen1Frauke Rudolf2Thorny Linda Haraldsdottir3Lamine Indjai4Rui Barai5Henning Beck-Nielsen6Morten Sodemann7Dorte Møller Jensen8Morten Bjerregaard-Andersen9INDEPTH NetworkINDEPTH NetworkINDEPTH NetworkINDEPTH NetworkThe National Diabetes Association (ANDD)The National Diabetes Association (ANDD)Odense University HospitalINDEPTH NetworkOdense University HospitalINDEPTH NetworkBackground The burden of diabetes mellitus in Sub-Saharan Africa is growing rapidly, and yet the prevalence and patient characteristics are still largely unknown. Objectives We analyzed clinical and demographic characteristics of Type 2 diabetes (T2DM) patients attending a diabetes clinic in Guinea-Bissau from February 2008 to April 2014, and estimated the prevalence and risk factors of unknown-impaired fasting plasma glucose (FPG) and diabetes, as well as excess mortality associated with T2DM. Methods We characterized T2DM patients attending the national diabetes clinic in Bissau. Diabetes was diagnosed based on FPG. We matched T2DM patients 1:1 with non-diabetes community controls on age and sex to determine relevant risk factors for T2DM using logistic regression. Furthermore, we matched patients 1:6 with community controls to assess long-term survival (until February 2019) in a Cox regression using calendar time as the underlying timescale. Verbal autopsies determined the cause of death among T2DM patients and controls. Results The mean age among T2DM was 50.6 (SD 11.1), and the mean FPG at first consultation was high (13.2 mmol/L (SD 5.1)). Ethnicity, family history of diabetes, hypertension, and anthropometrics differed among T2DM patients, community controls with impaired FPG, and healthy controls. Family history of diabetes (OR = 5.65, 95% CI: 3.10–10.3) and elevated waist circumference (2.33, 1.26–4.29) were significant risk factors for T2DM. 20.4% (59/289) of community controls had abnormal FPG. T2DM patients had an excess mortality hazard ratio of 3.53 (95%CI: 1.92–6.52). Deaths caused by bacterial infections, including foot ulcers, were more common among T2DM patients, compared with community controls (54% (7/13) vs. 19% (5/27) (P = 0.02)). Conclusion Several risk factors including were associated with T2DM in Guinea-Bissau. We found a high prevalence of elevated FPG among randomly selected community controls. In combination with higher mortality among T2DM patients, an urgent need for better treatment options and increased awareness.http://dx.doi.org/10.1080/16549716.2020.1802136type 2 diabetes mellitusafricaguinea-bissaucommunity burdenrisk factorsmortality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stine Byberg Camilla Bundesen Frauke Rudolf Thorny Linda Haraldsdottir Lamine Indjai Rui Barai Henning Beck-Nielsen Morten Sodemann Dorte Møller Jensen Morten Bjerregaard-Andersen |
spellingShingle |
Stine Byberg Camilla Bundesen Frauke Rudolf Thorny Linda Haraldsdottir Lamine Indjai Rui Barai Henning Beck-Nielsen Morten Sodemann Dorte Møller Jensen Morten Bjerregaard-Andersen Diabetes in urban Guinea-Bissau; patient characteristics, mortality and prevalence of undiagnosed dysglycemia Global Health Action type 2 diabetes mellitus africa guinea-bissau community burden risk factors mortality |
author_facet |
Stine Byberg Camilla Bundesen Frauke Rudolf Thorny Linda Haraldsdottir Lamine Indjai Rui Barai Henning Beck-Nielsen Morten Sodemann Dorte Møller Jensen Morten Bjerregaard-Andersen |
author_sort |
Stine Byberg |
title |
Diabetes in urban Guinea-Bissau; patient characteristics, mortality and prevalence of undiagnosed dysglycemia |
title_short |
Diabetes in urban Guinea-Bissau; patient characteristics, mortality and prevalence of undiagnosed dysglycemia |
title_full |
Diabetes in urban Guinea-Bissau; patient characteristics, mortality and prevalence of undiagnosed dysglycemia |
title_fullStr |
Diabetes in urban Guinea-Bissau; patient characteristics, mortality and prevalence of undiagnosed dysglycemia |
title_full_unstemmed |
Diabetes in urban Guinea-Bissau; patient characteristics, mortality and prevalence of undiagnosed dysglycemia |
title_sort |
diabetes in urban guinea-bissau; patient characteristics, mortality and prevalence of undiagnosed dysglycemia |
publisher |
Taylor & Francis Group |
series |
Global Health Action |
issn |
1654-9880 |
publishDate |
2020-12-01 |
description |
Background The burden of diabetes mellitus in Sub-Saharan Africa is growing rapidly, and yet the prevalence and patient characteristics are still largely unknown. Objectives We analyzed clinical and demographic characteristics of Type 2 diabetes (T2DM) patients attending a diabetes clinic in Guinea-Bissau from February 2008 to April 2014, and estimated the prevalence and risk factors of unknown-impaired fasting plasma glucose (FPG) and diabetes, as well as excess mortality associated with T2DM. Methods We characterized T2DM patients attending the national diabetes clinic in Bissau. Diabetes was diagnosed based on FPG. We matched T2DM patients 1:1 with non-diabetes community controls on age and sex to determine relevant risk factors for T2DM using logistic regression. Furthermore, we matched patients 1:6 with community controls to assess long-term survival (until February 2019) in a Cox regression using calendar time as the underlying timescale. Verbal autopsies determined the cause of death among T2DM patients and controls. Results The mean age among T2DM was 50.6 (SD 11.1), and the mean FPG at first consultation was high (13.2 mmol/L (SD 5.1)). Ethnicity, family history of diabetes, hypertension, and anthropometrics differed among T2DM patients, community controls with impaired FPG, and healthy controls. Family history of diabetes (OR = 5.65, 95% CI: 3.10–10.3) and elevated waist circumference (2.33, 1.26–4.29) were significant risk factors for T2DM. 20.4% (59/289) of community controls had abnormal FPG. T2DM patients had an excess mortality hazard ratio of 3.53 (95%CI: 1.92–6.52). Deaths caused by bacterial infections, including foot ulcers, were more common among T2DM patients, compared with community controls (54% (7/13) vs. 19% (5/27) (P = 0.02)). Conclusion Several risk factors including were associated with T2DM in Guinea-Bissau. We found a high prevalence of elevated FPG among randomly selected community controls. In combination with higher mortality among T2DM patients, an urgent need for better treatment options and increased awareness. |
topic |
type 2 diabetes mellitus africa guinea-bissau community burden risk factors mortality |
url |
http://dx.doi.org/10.1080/16549716.2020.1802136 |
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