Probing Structural Features and Binding Mode of 3-Arylpyrimidin-2,4-diones within Housefly γ-Aminobutyric Acid (GABA) Receptor

Probing Structural Features and Binding Mode of 3-Arylpyrimidin-2,4-diones within Housefly γ-Aminobutyric Acid (GABA) Receptor

In order to obtain structural features of 3-arylpyrimidin-2,4-diones emerged as promising inhibitors of insect γ-aminobutyric acid (GABA) receptor, a set of ligand-/receptor-based 3D-QSAR models for 60 derivatives are generated using Comparative Molecular Field Analysis (CoMFA) and Comparative Molec...

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Bibliographic Details
Main Authors:	Xiangya Kong, Yonghua Wang, Hong Zhang, Fangfang Wang, Lihui Zhang, Zhi Ma, Qinfan Li
Format:	Article
Language:	English
Published:	MDPI AG 2011-09-01
Series:	International Journal of Molecular Sciences
Subjects:	3-arylpyrimidin-2,4-diones GABA receptor 3D-QSAR homology modeling molecular dynamics simulation molecular docking
Online Access:	http://www.mdpi.com/1422-0067/12/9/6293/

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