The Role of Histone Protein Acetylation in Regulating Endothelial Function
Endothelial cell (EC), consisting of the innermost cellular layer of all types of vessels, is not only a barrier composer but also performing multiple functions in physiological processes. It actively controls the vascular tone and the extravasation of water, solutes, and macromolecules; modulates c...
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2021-04-01
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doaj-4d91bda92ceb4074bc6a1fa367c50c452021-04-28T06:40:44ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-04-01910.3389/fcell.2021.672447672447The Role of Histone Protein Acetylation in Regulating Endothelial FunctionZhi Fang0Zhi Fang1Xiang Wang2Xiaoran Sun3Wenquan Hu4Qing R. Miao5Department of Foundations of Medicine, New York University Long Island School of Medicine, Mineola, NY, United StatesDepartment of Neurology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Foundations of Medicine, New York University Long Island School of Medicine, Mineola, NY, United StatesDepartment of Foundations of Medicine, New York University Long Island School of Medicine, Mineola, NY, United StatesDepartment of Foundations of Medicine, New York University Long Island School of Medicine, Mineola, NY, United StatesDepartment of Foundations of Medicine, New York University Long Island School of Medicine, Mineola, NY, United StatesEndothelial cell (EC), consisting of the innermost cellular layer of all types of vessels, is not only a barrier composer but also performing multiple functions in physiological processes. It actively controls the vascular tone and the extravasation of water, solutes, and macromolecules; modulates circulating immune cells as well as platelet and leukocyte recruitment/adhesion and activation. In addition, EC also tightly keeps coagulation/fibrinolysis balance and plays a major role in angiogenesis. Therefore, endothelial dysfunction contributes to the pathogenesis of many diseases. Growing pieces of evidence suggest that histone protein acetylation, an epigenetic mark, is altered in ECs under different conditions, and the acetylation status change at different lysine sites on histone protein plays a key role in endothelial dysfunction and involved in hyperglycemia, hypertension, inflammatory disease, cancer and so on. In this review, we highlight the importance of histone acetylation in regulating endothelial functions and discuss the roles of histone acetylation across the transcriptional unit of protein-coding genes in ECs under different disease-related pathophysiological processes. Since histone acetylation changes are conserved and reversible, the knowledge of histone acetylation in endothelial function regulation could provide insights to develop epigenetic interventions in preventing or treating endothelial dysfunction-related diseases.https://www.frontiersin.org/articles/10.3389/fcell.2021.672447/fullepigenetic regulationhistone acetylationacetyltransferasedeacetylaseendothelial dysfunction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhi Fang Zhi Fang Xiang Wang Xiaoran Sun Wenquan Hu Qing R. Miao |
spellingShingle |
Zhi Fang Zhi Fang Xiang Wang Xiaoran Sun Wenquan Hu Qing R. Miao The Role of Histone Protein Acetylation in Regulating Endothelial Function Frontiers in Cell and Developmental Biology epigenetic regulation histone acetylation acetyltransferase deacetylase endothelial dysfunction |
author_facet |
Zhi Fang Zhi Fang Xiang Wang Xiaoran Sun Wenquan Hu Qing R. Miao |
author_sort |
Zhi Fang |
title |
The Role of Histone Protein Acetylation in Regulating Endothelial Function |
title_short |
The Role of Histone Protein Acetylation in Regulating Endothelial Function |
title_full |
The Role of Histone Protein Acetylation in Regulating Endothelial Function |
title_fullStr |
The Role of Histone Protein Acetylation in Regulating Endothelial Function |
title_full_unstemmed |
The Role of Histone Protein Acetylation in Regulating Endothelial Function |
title_sort |
role of histone protein acetylation in regulating endothelial function |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-04-01 |
description |
Endothelial cell (EC), consisting of the innermost cellular layer of all types of vessels, is not only a barrier composer but also performing multiple functions in physiological processes. It actively controls the vascular tone and the extravasation of water, solutes, and macromolecules; modulates circulating immune cells as well as platelet and leukocyte recruitment/adhesion and activation. In addition, EC also tightly keeps coagulation/fibrinolysis balance and plays a major role in angiogenesis. Therefore, endothelial dysfunction contributes to the pathogenesis of many diseases. Growing pieces of evidence suggest that histone protein acetylation, an epigenetic mark, is altered in ECs under different conditions, and the acetylation status change at different lysine sites on histone protein plays a key role in endothelial dysfunction and involved in hyperglycemia, hypertension, inflammatory disease, cancer and so on. In this review, we highlight the importance of histone acetylation in regulating endothelial functions and discuss the roles of histone acetylation across the transcriptional unit of protein-coding genes in ECs under different disease-related pathophysiological processes. Since histone acetylation changes are conserved and reversible, the knowledge of histone acetylation in endothelial function regulation could provide insights to develop epigenetic interventions in preventing or treating endothelial dysfunction-related diseases. |
topic |
epigenetic regulation histone acetylation acetyltransferase deacetylase endothelial dysfunction |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.672447/full |
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