Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.
In the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT). Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Mult...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
|
Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21750728/?tool=EBI |
id |
doaj-4d9eac0c8ccf4afe9140262af4369f85 |
---|---|
record_format |
Article |
spelling |
doaj-4d9eac0c8ccf4afe9140262af4369f852021-03-04T01:46:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0167e2174110.1371/journal.pone.0021741Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.Michael KraeusslingToni Ulrich WagnerManfred SchartlIn the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT). Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Multiple mechanisms, primarily the nucleocytoplasmic ratio, are supposed to control MBT activation. Unexpectedly, we find in the small teleost fish medaka (Oryzias latipes) that at very early stages, well before midblastula, cell division becomes asynchronous and cell volumes diverge. Furthermore, zygotic transcription is extensively activated already after the 64-cell stage. Thus, at least in medaka, the transition from maternal to zygotic transcription is uncoupled from the midblastula stage and not solely controlled by the nucleocytoplasmic ratio.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21750728/?tool=EBI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael Kraeussling Toni Ulrich Wagner Manfred Schartl |
spellingShingle |
Michael Kraeussling Toni Ulrich Wagner Manfred Schartl Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos. PLoS ONE |
author_facet |
Michael Kraeussling Toni Ulrich Wagner Manfred Schartl |
author_sort |
Michael Kraeussling |
title |
Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos. |
title_short |
Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos. |
title_full |
Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos. |
title_fullStr |
Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos. |
title_full_unstemmed |
Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos. |
title_sort |
highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2011-01-01 |
description |
In the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT). Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Multiple mechanisms, primarily the nucleocytoplasmic ratio, are supposed to control MBT activation. Unexpectedly, we find in the small teleost fish medaka (Oryzias latipes) that at very early stages, well before midblastula, cell division becomes asynchronous and cell volumes diverge. Furthermore, zygotic transcription is extensively activated already after the 64-cell stage. Thus, at least in medaka, the transition from maternal to zygotic transcription is uncoupled from the midblastula stage and not solely controlled by the nucleocytoplasmic ratio. |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21750728/?tool=EBI |
work_keys_str_mv |
AT michaelkraeussling highlyasynchronousandasymmetriccleavagedivisionsaccompanyearlytranscriptionalactivityinpreblastulamedakaembryos AT toniulrichwagner highlyasynchronousandasymmetriccleavagedivisionsaccompanyearlytranscriptionalactivityinpreblastulamedakaembryos AT manfredschartl highlyasynchronousandasymmetriccleavagedivisionsaccompanyearlytranscriptionalactivityinpreblastulamedakaembryos |
_version_ |
1714809265240145920 |