Nevirapine, sodium concentration and HIV-1 RNA in breast milk and plasma among HIV-infected women receiving short-course antiretroviral prophylaxis.
Risk factors for breast milk transmission of HIV-1 from mother to child include high plasma and breast milk viral load, low maternal CD4 count and breast pathology such as mastitis.To determine the impact of nevirapine and subclinical mastitis on HIV-1 RNA in maternal plasma and breast milk after in...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4374672?pdf=render |
id |
doaj-4d9fc74d3d7247399d3555f604bef39a |
---|---|
record_format |
Article |
spelling |
doaj-4d9fc74d3d7247399d3555f604bef39a2020-11-25T01:01:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e012111110.1371/journal.pone.0121111Nevirapine, sodium concentration and HIV-1 RNA in breast milk and plasma among HIV-infected women receiving short-course antiretroviral prophylaxis.Kirsten Salado-RasmussenZahra P TheilgaardMercy G ChiduoIb C BygbjergJan GerstoftMargrethe Lüneborg-NielsenMartha LemngeTerese L KatzensteinRisk factors for breast milk transmission of HIV-1 from mother to child include high plasma and breast milk viral load, low maternal CD4 count and breast pathology such as mastitis.To determine the impact of nevirapine and subclinical mastitis on HIV-1 RNA in maternal plasma and breast milk after intrapartum single-dose nevirapine combined with either 1-week tail of Combivir (zidovudine/lamivudine) or single-dose Truvada (tenofovir/emtricitabine).Maternal plasma and bilateral breast milk samples were collected between April 2008 and April 2011 at 1, 4 and 6 weeks postpartum from HIV-infected Tanzanian women. Moreover, plasma samples were collected at delivery from mother and infant.HIV-1 RNA was quantified in 1,212 breast milk samples from 273 women. At delivery, 96% of the women and 99% of the infants had detectable nevirapine in plasma with a median (interquartile range, IQR) of 1.5 μg/mL (0.75-2.20 μg/mL) and 1.04 μg/mL (0.39-1.71 μg/mL), respectively (P < 0.001). At 1 week postpartum, 93% and 98% of the women had detectable nevirapine in plasma and breast milk, with a median (IQR) of 0.13 μg/mL (0.13-0.39 μg/mL) and 0.22 μg/mL (0.13-0.34 μg/mL), respectively. Maternal plasma and breast milk HIV-1 RNA correlated at all visits (R = 0.48, R = 0.7, R = 0.59; all P = 0.01). Subclinical mastitis was detected in 67% of the women at some time during 6 weeks, and in 38% of the breast milk samples. Breast milk samples with subclinical mastitis had significantly higher HIV-1 RNA at 1, 4 and 6 weeks (all P < 0.05).After short-course antiretroviral prophylaxis, nevirapine was detectable in most infant cord blood samples and the concentration in maternal plasma and breast milk was high through week 1 accompanied by suppressed HIV-1 RNA in plasma and breast milk.http://europepmc.org/articles/PMC4374672?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kirsten Salado-Rasmussen Zahra P Theilgaard Mercy G Chiduo Ib C Bygbjerg Jan Gerstoft Margrethe Lüneborg-Nielsen Martha Lemnge Terese L Katzenstein |
spellingShingle |
Kirsten Salado-Rasmussen Zahra P Theilgaard Mercy G Chiduo Ib C Bygbjerg Jan Gerstoft Margrethe Lüneborg-Nielsen Martha Lemnge Terese L Katzenstein Nevirapine, sodium concentration and HIV-1 RNA in breast milk and plasma among HIV-infected women receiving short-course antiretroviral prophylaxis. PLoS ONE |
author_facet |
Kirsten Salado-Rasmussen Zahra P Theilgaard Mercy G Chiduo Ib C Bygbjerg Jan Gerstoft Margrethe Lüneborg-Nielsen Martha Lemnge Terese L Katzenstein |
author_sort |
Kirsten Salado-Rasmussen |
title |
Nevirapine, sodium concentration and HIV-1 RNA in breast milk and plasma among HIV-infected women receiving short-course antiretroviral prophylaxis. |
title_short |
Nevirapine, sodium concentration and HIV-1 RNA in breast milk and plasma among HIV-infected women receiving short-course antiretroviral prophylaxis. |
title_full |
Nevirapine, sodium concentration and HIV-1 RNA in breast milk and plasma among HIV-infected women receiving short-course antiretroviral prophylaxis. |
title_fullStr |
Nevirapine, sodium concentration and HIV-1 RNA in breast milk and plasma among HIV-infected women receiving short-course antiretroviral prophylaxis. |
title_full_unstemmed |
Nevirapine, sodium concentration and HIV-1 RNA in breast milk and plasma among HIV-infected women receiving short-course antiretroviral prophylaxis. |
title_sort |
nevirapine, sodium concentration and hiv-1 rna in breast milk and plasma among hiv-infected women receiving short-course antiretroviral prophylaxis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
Risk factors for breast milk transmission of HIV-1 from mother to child include high plasma and breast milk viral load, low maternal CD4 count and breast pathology such as mastitis.To determine the impact of nevirapine and subclinical mastitis on HIV-1 RNA in maternal plasma and breast milk after intrapartum single-dose nevirapine combined with either 1-week tail of Combivir (zidovudine/lamivudine) or single-dose Truvada (tenofovir/emtricitabine).Maternal plasma and bilateral breast milk samples were collected between April 2008 and April 2011 at 1, 4 and 6 weeks postpartum from HIV-infected Tanzanian women. Moreover, plasma samples were collected at delivery from mother and infant.HIV-1 RNA was quantified in 1,212 breast milk samples from 273 women. At delivery, 96% of the women and 99% of the infants had detectable nevirapine in plasma with a median (interquartile range, IQR) of 1.5 μg/mL (0.75-2.20 μg/mL) and 1.04 μg/mL (0.39-1.71 μg/mL), respectively (P < 0.001). At 1 week postpartum, 93% and 98% of the women had detectable nevirapine in plasma and breast milk, with a median (IQR) of 0.13 μg/mL (0.13-0.39 μg/mL) and 0.22 μg/mL (0.13-0.34 μg/mL), respectively. Maternal plasma and breast milk HIV-1 RNA correlated at all visits (R = 0.48, R = 0.7, R = 0.59; all P = 0.01). Subclinical mastitis was detected in 67% of the women at some time during 6 weeks, and in 38% of the breast milk samples. Breast milk samples with subclinical mastitis had significantly higher HIV-1 RNA at 1, 4 and 6 weeks (all P < 0.05).After short-course antiretroviral prophylaxis, nevirapine was detectable in most infant cord blood samples and the concentration in maternal plasma and breast milk was high through week 1 accompanied by suppressed HIV-1 RNA in plasma and breast milk. |
url |
http://europepmc.org/articles/PMC4374672?pdf=render |
work_keys_str_mv |
AT kirstensaladorasmussen nevirapinesodiumconcentrationandhiv1rnainbreastmilkandplasmaamonghivinfectedwomenreceivingshortcourseantiretroviralprophylaxis AT zahraptheilgaard nevirapinesodiumconcentrationandhiv1rnainbreastmilkandplasmaamonghivinfectedwomenreceivingshortcourseantiretroviralprophylaxis AT mercygchiduo nevirapinesodiumconcentrationandhiv1rnainbreastmilkandplasmaamonghivinfectedwomenreceivingshortcourseantiretroviralprophylaxis AT ibcbygbjerg nevirapinesodiumconcentrationandhiv1rnainbreastmilkandplasmaamonghivinfectedwomenreceivingshortcourseantiretroviralprophylaxis AT jangerstoft nevirapinesodiumconcentrationandhiv1rnainbreastmilkandplasmaamonghivinfectedwomenreceivingshortcourseantiretroviralprophylaxis AT margretheluneborgnielsen nevirapinesodiumconcentrationandhiv1rnainbreastmilkandplasmaamonghivinfectedwomenreceivingshortcourseantiretroviralprophylaxis AT marthalemnge nevirapinesodiumconcentrationandhiv1rnainbreastmilkandplasmaamonghivinfectedwomenreceivingshortcourseantiretroviralprophylaxis AT tereselkatzenstein nevirapinesodiumconcentrationandhiv1rnainbreastmilkandplasmaamonghivinfectedwomenreceivingshortcourseantiretroviralprophylaxis |
_version_ |
1725208145289019392 |