Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice[S]

Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice[S]

Macrophages play crucial roles in the formation of atherosclerotic lesions. Akt, a serine/threonine protein kinase B, is vital for cell proliferation, migration, and survival. Macrophages express three Akt isoforms, Akt1, Akt2, and Akt3, but the roles of Akt1 and Akt2 in atherosclerosis in vivo rema...

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Bibliographic Details
Main Authors: Vladimir R. Babaev, Katie E. Hebron, Carrie B. Wiese, Cynthia L. Toth, Lei Ding, Youmin Zhang, James M. May, Sergio Fazio, Kasey C. Vickers, MacRae F. Linton
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Journal of Lipid Research
Subjects:
macrophages/monocytes
cell signaling
apoptosis
foam cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520349828

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