Recent Developments in the Suzuki–Miyaura Reaction Using Nitroarenes as Electrophilic Coupling Reagents

• Main Authors: Lou Rocard, Piétrick Hudhomme
• Format: Article
• Language: English
• Published: MDPI AG 2019-02-01
• Series: Catalysts
• Subjects: Suzuki–Miyaura; nitroarene; palladium-catalyzed cross-coupling
• Online Access: https://www.mdpi.com/2073-4344/9/3/213

Palladium-catalyzed cross-coupling reactions are nowadays essential in organic synthesis for the construction of C⁻C, C⁻N, C⁻O, and other C-heteroatom bonds. The 2010 Nobel Prize in Chemistry to Richard F. Heck, Ei-ichi Negishi, and Akira Suzuki was awarded for the discovery of these reactions. These great advances for organic chemists stimulated intense research efforts worldwide dedicated to studying these reactions. Among them, the Suzuki⁻Miyaura coupling (SMC) reaction, which usually involves an organoboron reagent and an organic halide or triflate in the presence of a base and a palladium catalyst, has become, in the last few decades, one of the most popular tools for the creation of C⁻C bonds. In this review, we present recent progress concerning the SMC reaction with the original use of nitroarenes as electrophilic coupling partners reacting with the organoboron reagent.