Comparative Study of the Prophylactic Effect of Intravenous or Gargling Dexamethasone in Reducing Postextubation Sore Throat and Cough
Background: Sore throat, cough and hoarseness after tracheal extubation are common complications after surgery. Due to the proven effect of dexamethasone on reducing these complications, in this study, we compared the prophylactic effect of intravenous dexamethasone and dexamethasone gargle on sore...
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Tehran University of Medical Sciences
2021-02-01
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doaj-4dafabcb2a314d36984d72fdc06921b52021-09-11T04:10:33ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492021-02-017110.18502/aacc.v7i1.5473Comparative Study of the Prophylactic Effect of Intravenous or Gargling Dexamethasone in Reducing Postextubation Sore Throat and CoughReihanak Talakoub0Keyvan Bagheri1Mitra Jabalameli2Fahimeh Salehi3Hamidreza Shetabi4Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Background: Sore throat, cough and hoarseness after tracheal extubation are common complications after surgery. Due to the proven effect of dexamethasone on reducing these complications, in this study, we compared the prophylactic effect of intravenous dexamethasone and dexamethasone gargle on sore throat and cough after extubation. Methods: In this clinical trial study, 96 patients between the ages of 18-64 years who underwent elective surgery and intubation under general anesthesia were randomly divided into three groups, respectively, the first group received 6 mg dexamethasone gargle. The second group received 6 mg intravenous dexamethasone and the third group received normal saline. The frequency of cough and sore throat were assessed and compared in these three groups. Results: There was no significant difference between the three groups based on hemodynamic variables and demographic data (P> 0.05). The frequency of cough in the first (1.54± 2.82) and second (1.57±2.73) groups was less than the third group (1.79±3.14), but this difference was not statistically significant (P>0.66). The mean severity of sore throat in the second group and then in the first group was lower at the time of entry into recovery and 2 hours after surgery, than the third group. (P <0.005) Also, the mean severity of sore throat in the second group and then the first group in 24 hours after surgery was significantly lower than the third group. (P <0.005). Conclusion: Prophylactic single-dose intravenous dexamethasone is more effective than dexamethasone gargle in reducing sore throat due to endotracheal intubation. Also, gargling and intravenous injection of dexamethasone, both are effective in reducing postoperative cough without any side effects after extubation. https://aacc.tums.ac.ir/index.php/aacc/article/view/309Dexamethasoneintravenousgarglecoughsore throatpostextubation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Reihanak Talakoub Keyvan Bagheri Mitra Jabalameli Fahimeh Salehi Hamidreza Shetabi |
spellingShingle |
Reihanak Talakoub Keyvan Bagheri Mitra Jabalameli Fahimeh Salehi Hamidreza Shetabi Comparative Study of the Prophylactic Effect of Intravenous or Gargling Dexamethasone in Reducing Postextubation Sore Throat and Cough Archives of Anesthesia and Critical Care Dexamethasone intravenous gargle cough sore throat postextubation |
author_facet |
Reihanak Talakoub Keyvan Bagheri Mitra Jabalameli Fahimeh Salehi Hamidreza Shetabi |
author_sort |
Reihanak Talakoub |
title |
Comparative Study of the Prophylactic Effect of Intravenous or Gargling Dexamethasone in Reducing Postextubation Sore Throat and Cough |
title_short |
Comparative Study of the Prophylactic Effect of Intravenous or Gargling Dexamethasone in Reducing Postextubation Sore Throat and Cough |
title_full |
Comparative Study of the Prophylactic Effect of Intravenous or Gargling Dexamethasone in Reducing Postextubation Sore Throat and Cough |
title_fullStr |
Comparative Study of the Prophylactic Effect of Intravenous or Gargling Dexamethasone in Reducing Postextubation Sore Throat and Cough |
title_full_unstemmed |
Comparative Study of the Prophylactic Effect of Intravenous or Gargling Dexamethasone in Reducing Postextubation Sore Throat and Cough |
title_sort |
comparative study of the prophylactic effect of intravenous or gargling dexamethasone in reducing postextubation sore throat and cough |
publisher |
Tehran University of Medical Sciences |
series |
Archives of Anesthesia and Critical Care |
issn |
2423-5849 |
publishDate |
2021-02-01 |
description |
Background: Sore throat, cough and hoarseness after tracheal extubation are common complications after surgery. Due to the proven effect of dexamethasone on reducing these complications, in this study, we compared the prophylactic effect of intravenous dexamethasone and dexamethasone gargle on sore throat and cough after extubation.
Methods: In this clinical trial study, 96 patients between the ages of 18-64 years who underwent elective surgery and intubation under general anesthesia were randomly divided into three groups, respectively, the first group received 6 mg dexamethasone gargle. The second group received 6 mg intravenous dexamethasone and the third group received normal saline. The frequency of cough and sore throat were assessed and compared in these three groups.
Results: There was no significant difference between the three groups based on hemodynamic variables and demographic data (P> 0.05). The frequency of cough in the first (1.54± 2.82) and second (1.57±2.73) groups was less than the third group (1.79±3.14), but this difference was not statistically significant (P>0.66). The mean severity of sore throat in the second group and then in the first group was lower at the time of entry into recovery and 2 hours after surgery, than the third group. (P <0.005) Also, the mean severity of sore throat in the second group and then the first group in 24 hours after surgery was significantly lower than the third group. (P <0.005).
Conclusion: Prophylactic single-dose intravenous dexamethasone is more effective than dexamethasone gargle in reducing sore throat due to endotracheal intubation. Also, gargling and intravenous injection of dexamethasone, both are effective in reducing postoperative cough without any side effects after extubation.
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topic |
Dexamethasone intravenous gargle cough sore throat postextubation |
url |
https://aacc.tums.ac.ir/index.php/aacc/article/view/309 |
work_keys_str_mv |
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