Extracellular Vesicles and Autophagy in Osteoarthritis
Osteoarthritis (OA) is a type of chronic joint disease that is characterized by the degeneration and loss of articular cartilage and hyperplasia of the synovium and subchondral bone. There is reasonable knowledge about articular cartilage physiology, biochemistry, and chondrocyte metabolism. However...
Main Authors: | , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Hindawi Limited
2016-01-01
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2016/2428915 |
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doaj-4db21474950d46eba9a374a85f4eab8d |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tianyang Gao Weimin Guo Mingxue Chen Jingxiang Huang Zhiguo Yuan Yu Zhang Mingjie Wang Penghao Li Jiang Peng Aiyuan Wang Yu Wang Xiang Sui Li Zhang Wenjing Xu Shibi Lu Xifeng Zhang Shuyun Liu Quanyi Guo |
spellingShingle |
Tianyang Gao Weimin Guo Mingxue Chen Jingxiang Huang Zhiguo Yuan Yu Zhang Mingjie Wang Penghao Li Jiang Peng Aiyuan Wang Yu Wang Xiang Sui Li Zhang Wenjing Xu Shibi Lu Xifeng Zhang Shuyun Liu Quanyi Guo Extracellular Vesicles and Autophagy in Osteoarthritis BioMed Research International |
author_facet |
Tianyang Gao Weimin Guo Mingxue Chen Jingxiang Huang Zhiguo Yuan Yu Zhang Mingjie Wang Penghao Li Jiang Peng Aiyuan Wang Yu Wang Xiang Sui Li Zhang Wenjing Xu Shibi Lu Xifeng Zhang Shuyun Liu Quanyi Guo |
author_sort |
Tianyang Gao |
title |
Extracellular Vesicles and Autophagy in Osteoarthritis |
title_short |
Extracellular Vesicles and Autophagy in Osteoarthritis |
title_full |
Extracellular Vesicles and Autophagy in Osteoarthritis |
title_fullStr |
Extracellular Vesicles and Autophagy in Osteoarthritis |
title_full_unstemmed |
Extracellular Vesicles and Autophagy in Osteoarthritis |
title_sort |
extracellular vesicles and autophagy in osteoarthritis |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2016-01-01 |
description |
Osteoarthritis (OA) is a type of chronic joint disease that is characterized by the degeneration and loss of articular cartilage and hyperplasia of the synovium and subchondral bone. There is reasonable knowledge about articular cartilage physiology, biochemistry, and chondrocyte metabolism. However, the etiology and pathogenesis of OA remain unclear and need urgent clarification to guide the early diagnosis and treatment of OA. Extracellular vesicles (EVs) are small membrane-linking particles that are released from cells. In recent decades, several special biological properties have been found in EV, especially in terms of cartilage. Autophagy plays a critical role in the regulation of cellular homeostasis. Likewise, more and more research has gradually focused on the effect of autophagy on chondrocyte proliferation and function in OA. The synthesis and release of EV are closely associated with autophagy. At the same time, both EV and autophagy play a role in OA development. Based on the mechanism of EV and autophagy in OA development, EV may be beneficial in the early diagnosis of OA; on the other hand, the combination of EV and autophagy-related regulatory drugs may provide insight into possible OA therapeutic strategies. |
url |
http://dx.doi.org/10.1155/2016/2428915 |
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doaj-4db21474950d46eba9a374a85f4eab8d2020-11-25T01:13:29ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/24289152428915Extracellular Vesicles and Autophagy in OsteoarthritisTianyang Gao0Weimin Guo1Mingxue Chen2Jingxiang Huang3Zhiguo Yuan4Yu Zhang5Mingjie Wang6Penghao Li7Jiang Peng8Aiyuan Wang9Yu Wang10Xiang Sui11Li Zhang12Wenjing Xu13Shibi Lu14Xifeng Zhang15Shuyun Liu16Quanyi Guo17Institute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaMinimal Invasive Spine Surgery Center, Spine Division of Orthopaedic Department, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaOsteoarthritis (OA) is a type of chronic joint disease that is characterized by the degeneration and loss of articular cartilage and hyperplasia of the synovium and subchondral bone. There is reasonable knowledge about articular cartilage physiology, biochemistry, and chondrocyte metabolism. However, the etiology and pathogenesis of OA remain unclear and need urgent clarification to guide the early diagnosis and treatment of OA. Extracellular vesicles (EVs) are small membrane-linking particles that are released from cells. In recent decades, several special biological properties have been found in EV, especially in terms of cartilage. Autophagy plays a critical role in the regulation of cellular homeostasis. Likewise, more and more research has gradually focused on the effect of autophagy on chondrocyte proliferation and function in OA. The synthesis and release of EV are closely associated with autophagy. At the same time, both EV and autophagy play a role in OA development. Based on the mechanism of EV and autophagy in OA development, EV may be beneficial in the early diagnosis of OA; on the other hand, the combination of EV and autophagy-related regulatory drugs may provide insight into possible OA therapeutic strategies.http://dx.doi.org/10.1155/2016/2428915 |