Progress of Pharmaceutical Continuous Crystallization
Crystallization is an important unit operation in the pharmaceutical industry. At present, most pharmaceutical crystallization processes are performed in batches. However, due to product variability from batch to batch and to the low productivity of batch crystallization, continuous crystallization...
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doaj-4db9f00fb3a54b05aac41d86b806e0252020-11-24T21:03:04ZengElsevierEngineering2095-80992017-06-013335436410.1016/J.ENG.2017.03.023Progress of Pharmaceutical Continuous CrystallizationDejiang Zhang0Shijie Xu1Shichao Du2Jingkang Wang3Junbo Gong4School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, ChinaCrystallization is an important unit operation in the pharmaceutical industry. At present, most pharmaceutical crystallization processes are performed in batches. However, due to product variability from batch to batch and to the low productivity of batch crystallization, continuous crystallization is gaining increasing attention. In the past few years, progress has been made to allow the products of continuous crystallization to meet different requirements. This review summarizes the progress in pharmaceutical continuous crystallization from a product engineering perspective. The advantages and disadvantages of different types of continuous crystallization are compared, with the main difference between the two main types of crystallizers being their difference in residence time distribution. Approaches that use continuous crystallization to meet different quality requirements are summarized. Continuous crystallization has advantages in terms of size and morphology control. However, it also has the problem of a process yield that may be lower than that of a batch process, especially in the production of chirality crystals. Finally, different control strategies are compared.http://www.sciencedirect.com/science/article/pii/S2095809917304277Continuous crystallizationPharmaceuticalMSMPRTubular crystallizerControl strategy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dejiang Zhang Shijie Xu Shichao Du Jingkang Wang Junbo Gong |
spellingShingle |
Dejiang Zhang Shijie Xu Shichao Du Jingkang Wang Junbo Gong Progress of Pharmaceutical Continuous Crystallization Engineering Continuous crystallization Pharmaceutical MSMPR Tubular crystallizer Control strategy |
author_facet |
Dejiang Zhang Shijie Xu Shichao Du Jingkang Wang Junbo Gong |
author_sort |
Dejiang Zhang |
title |
Progress of Pharmaceutical Continuous Crystallization |
title_short |
Progress of Pharmaceutical Continuous Crystallization |
title_full |
Progress of Pharmaceutical Continuous Crystallization |
title_fullStr |
Progress of Pharmaceutical Continuous Crystallization |
title_full_unstemmed |
Progress of Pharmaceutical Continuous Crystallization |
title_sort |
progress of pharmaceutical continuous crystallization |
publisher |
Elsevier |
series |
Engineering |
issn |
2095-8099 |
publishDate |
2017-06-01 |
description |
Crystallization is an important unit operation in the pharmaceutical industry. At present, most pharmaceutical crystallization processes are performed in batches. However, due to product variability from batch to batch and to the low productivity of batch crystallization, continuous crystallization is gaining increasing attention. In the past few years, progress has been made to allow the products of continuous crystallization to meet different requirements. This review summarizes the progress in pharmaceutical continuous crystallization from a product engineering perspective. The advantages and disadvantages of different types of continuous crystallization are compared, with the main difference between the two main types of crystallizers being their difference in residence time distribution. Approaches that use continuous crystallization to meet different quality requirements are summarized. Continuous crystallization has advantages in terms of size and morphology control. However, it also has the problem of a process yield that may be lower than that of a batch process, especially in the production of chirality crystals. Finally, different control strategies are compared. |
topic |
Continuous crystallization Pharmaceutical MSMPR Tubular crystallizer Control strategy |
url |
http://www.sciencedirect.com/science/article/pii/S2095809917304277 |
work_keys_str_mv |
AT dejiangzhang progressofpharmaceuticalcontinuouscrystallization AT shijiexu progressofpharmaceuticalcontinuouscrystallization AT shichaodu progressofpharmaceuticalcontinuouscrystallization AT jingkangwang progressofpharmaceuticalcontinuouscrystallization AT junbogong progressofpharmaceuticalcontinuouscrystallization |
_version_ |
1716774251342594048 |