IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake
The human cytokine interleukin (IL)-37 is an anti-inflammatory member of the IL-1 family of cytokines. Transgenic expression of IL-37 in mice protects them from diet-induced obesity and associated metabolic complications including dyslipidemia, inflammation and insulin resistance. The precise mechan...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-08-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/19/8/2264 |
id |
doaj-4dbb2c7596974308ac867267ee07ce91 |
---|---|
record_format |
Article |
spelling |
doaj-4dbb2c7596974308ac867267ee07ce912020-11-24T21:06:13ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-08-01198226410.3390/ijms19082264ijms19082264IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food IntakeEline N. Kuipers0Andrea D. van Dam1Dov B. Ballak2Ellemiek A. de Wit3Charles A. Dinarello4Rinke Stienstra5Janna A. van Diepen6Patrick C.N. Rensen7Mariëtte R. Boon8Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Post Zone C7Q, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Post Zone C7Q, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Medicine, University of Colorado, Aurora, CO 80045, USADepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Post Zone C7Q, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Medicine, University of Colorado, Aurora, CO 80045, USADepartment of General Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, 6525 HP Nijmegen, The NetherlandsDepartment of General Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, 6525 HP Nijmegen, The NetherlandsDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Post Zone C7Q, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Post Zone C7Q, P.O. Box 9600, 2300 RC Leiden, The NetherlandsThe human cytokine interleukin (IL)-37 is an anti-inflammatory member of the IL-1 family of cytokines. Transgenic expression of IL-37 in mice protects them from diet-induced obesity and associated metabolic complications including dyslipidemia, inflammation and insulin resistance. The precise mechanism of action leading to these beneficial metabolic effects is not entirely known. Therefore, we aimed to assess in detail the effect of transgenic IL-37 expression on energy balance, including food intake and energy expenditure. Feeding homozygous IL-37 transgenic mice and wild-type (WT) control mice a high-fat diet (HFD; 45% kcal palm fat) for 6 weeks showed that IL-37 reduced body weight related to a marked decrease in food intake. Subsequent mechanistic studies in mice with heterozygous IL-37 expression versus WT littermates, fed the HFD for 18 weeks, confirmed that IL-37 reduces food intake, which led to a decrease in lean body mass, but did not reduce fat mass and plasma lipid levels or alterations in energy expenditure independent of lean body mass. Taken together, this suggests that IL-37 reduces lean body mass by reducing food intake.http://www.mdpi.com/1422-0067/19/8/2264IL-37energy metabolismfood intakehigh fat diet |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eline N. Kuipers Andrea D. van Dam Dov B. Ballak Ellemiek A. de Wit Charles A. Dinarello Rinke Stienstra Janna A. van Diepen Patrick C.N. Rensen Mariëtte R. Boon |
spellingShingle |
Eline N. Kuipers Andrea D. van Dam Dov B. Ballak Ellemiek A. de Wit Charles A. Dinarello Rinke Stienstra Janna A. van Diepen Patrick C.N. Rensen Mariëtte R. Boon IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake International Journal of Molecular Sciences IL-37 energy metabolism food intake high fat diet |
author_facet |
Eline N. Kuipers Andrea D. van Dam Dov B. Ballak Ellemiek A. de Wit Charles A. Dinarello Rinke Stienstra Janna A. van Diepen Patrick C.N. Rensen Mariëtte R. Boon |
author_sort |
Eline N. Kuipers |
title |
IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake |
title_short |
IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake |
title_full |
IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake |
title_fullStr |
IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake |
title_full_unstemmed |
IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake |
title_sort |
il-37 expression reduces lean body mass in mice by reducing food intake |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-08-01 |
description |
The human cytokine interleukin (IL)-37 is an anti-inflammatory member of the IL-1 family of cytokines. Transgenic expression of IL-37 in mice protects them from diet-induced obesity and associated metabolic complications including dyslipidemia, inflammation and insulin resistance. The precise mechanism of action leading to these beneficial metabolic effects is not entirely known. Therefore, we aimed to assess in detail the effect of transgenic IL-37 expression on energy balance, including food intake and energy expenditure. Feeding homozygous IL-37 transgenic mice and wild-type (WT) control mice a high-fat diet (HFD; 45% kcal palm fat) for 6 weeks showed that IL-37 reduced body weight related to a marked decrease in food intake. Subsequent mechanistic studies in mice with heterozygous IL-37 expression versus WT littermates, fed the HFD for 18 weeks, confirmed that IL-37 reduces food intake, which led to a decrease in lean body mass, but did not reduce fat mass and plasma lipid levels or alterations in energy expenditure independent of lean body mass. Taken together, this suggests that IL-37 reduces lean body mass by reducing food intake. |
topic |
IL-37 energy metabolism food intake high fat diet |
url |
http://www.mdpi.com/1422-0067/19/8/2264 |
work_keys_str_mv |
AT elinenkuipers il37expressionreducesleanbodymassinmicebyreducingfoodintake AT andreadvandam il37expressionreducesleanbodymassinmicebyreducingfoodintake AT dovbballak il37expressionreducesleanbodymassinmicebyreducingfoodintake AT ellemiekadewit il37expressionreducesleanbodymassinmicebyreducingfoodintake AT charlesadinarello il37expressionreducesleanbodymassinmicebyreducingfoodintake AT rinkestienstra il37expressionreducesleanbodymassinmicebyreducingfoodintake AT jannaavandiepen il37expressionreducesleanbodymassinmicebyreducingfoodintake AT patrickcnrensen il37expressionreducesleanbodymassinmicebyreducingfoodintake AT marietterboon il37expressionreducesleanbodymassinmicebyreducingfoodintake |
_version_ |
1716766364703653888 |