IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake

IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake

The human cytokine interleukin (IL)-37 is an anti-inflammatory member of the IL-1 family of cytokines. Transgenic expression of IL-37 in mice protects them from diet-induced obesity and associated metabolic complications including dyslipidemia, inflammation and insulin resistance. The precise mechan...

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Bibliographic Details
Main Authors: Eline N. Kuipers, Andrea D. van Dam, Dov B. Ballak, Ellemiek A. de Wit, Charles A. Dinarello, Rinke Stienstra, Janna A. van Diepen, Patrick C.N. Rensen, Mariëtte R. Boon
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
IL-37
energy metabolism
food intake
high fat diet
Online Access:http://www.mdpi.com/1422-0067/19/8/2264

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