Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans
Levels of perfluorocarboxylates (PFCAs) in biological compartments have been known for some time but their transport routes and distribution patterns are not properly elucidated. The opinions diverge whether the exposure of the general population occurs indirect through precursors or direct via PFCA...
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doaj-4dbc4ae49b2445c4a7bb5eb757b7e70e2020-11-24T21:55:24ZengElsevierEnvironment International0160-41202013-01-0151812Biotransformation of fluorotelomer compound to perfluorocarboxylates in humansHelena Nilsson0Anna Kärrman1Anna Rotander2Bert van Bavel3Gunilla Lindström4Håkan Westberg5Man-Technology-Environment (MTM) Research Centre, Örebro University, SE-701 82 Örebro, Sweden; Corresponding author. Tel.: +46 19 30 12 09; fax: +46 19 30 35 66.Man-Technology-Environment (MTM) Research Centre, Örebro University, SE-701 82 Örebro, SwedenMan-Technology-Environment (MTM) Research Centre, Örebro University, SE-701 82 Örebro, SwedenMan-Technology-Environment (MTM) Research Centre, Örebro University, SE-701 82 Örebro, SwedenMan-Technology-Environment (MTM) Research Centre, Örebro University, SE-701 82 Örebro, SwedenMan-Technology-Environment (MTM) Research Centre, Örebro University, SE-701 82 Örebro, Sweden; Department of Occupational and Environmental Medicine, Örebro University Hospital, SE-701 85 Örebro, SwedenLevels of perfluorocarboxylates (PFCAs) in biological compartments have been known for some time but their transport routes and distribution patterns are not properly elucidated. The opinions diverge whether the exposure of the general population occurs indirect through precursors or direct via PFCAs. Previous results showed that ski wax technicians are exposed to levels up to 92 000 ng/m3 of 8:2 fluorotelomer alcohol (FTOH) via air and have elevated blood levels of PFCAs. Blood samples were collected in 2007–2011 and analyzed for C4–C18 PFCAs, 6:2, 8:2 and 10:2 unsaturated fluorotelomer acids (FTUCAs) and 3:3, 5:3 and 7:3 fluorotelomer acids (FTCAs) using UPLC–MS/MS. Perfluorooctanoic acid (PFOA) was detected in levels ranging from 1.90 to 628 ng/mL whole blood (wb). Metabolic intermediates 5:3 and 7:3 FTCA were detected in all samples at levels up to 6.1 and 3.9 ng/mL wb. 6:2, 8:2 and 10:2 FTUCAs showed maximum levels of 0.07, 0.64 and 0.11 ng/mL wb. Also, for the first time levels of PFHxDA and PFOcDA were detected in the human blood at mean concentrations up to 4.22 ng/mL wb and 4.25 ng/mL wb respectively.The aim of this study was to determine concentrations of PFCAs and FTOH metabolites in blood from ski wax technicians. Keywords: FTOH, PFOA, FTCA, Precursor, Biotransformation, Ski waxhttp://www.sciencedirect.com/science/article/pii/S0160412012001997 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Helena Nilsson Anna Kärrman Anna Rotander Bert van Bavel Gunilla Lindström Håkan Westberg |
spellingShingle |
Helena Nilsson Anna Kärrman Anna Rotander Bert van Bavel Gunilla Lindström Håkan Westberg Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans Environment International |
author_facet |
Helena Nilsson Anna Kärrman Anna Rotander Bert van Bavel Gunilla Lindström Håkan Westberg |
author_sort |
Helena Nilsson |
title |
Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans |
title_short |
Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans |
title_full |
Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans |
title_fullStr |
Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans |
title_full_unstemmed |
Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans |
title_sort |
biotransformation of fluorotelomer compound to perfluorocarboxylates in humans |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2013-01-01 |
description |
Levels of perfluorocarboxylates (PFCAs) in biological compartments have been known for some time but their transport routes and distribution patterns are not properly elucidated. The opinions diverge whether the exposure of the general population occurs indirect through precursors or direct via PFCAs. Previous results showed that ski wax technicians are exposed to levels up to 92 000 ng/m3 of 8:2 fluorotelomer alcohol (FTOH) via air and have elevated blood levels of PFCAs. Blood samples were collected in 2007–2011 and analyzed for C4–C18 PFCAs, 6:2, 8:2 and 10:2 unsaturated fluorotelomer acids (FTUCAs) and 3:3, 5:3 and 7:3 fluorotelomer acids (FTCAs) using UPLC–MS/MS. Perfluorooctanoic acid (PFOA) was detected in levels ranging from 1.90 to 628 ng/mL whole blood (wb). Metabolic intermediates 5:3 and 7:3 FTCA were detected in all samples at levels up to 6.1 and 3.9 ng/mL wb. 6:2, 8:2 and 10:2 FTUCAs showed maximum levels of 0.07, 0.64 and 0.11 ng/mL wb. Also, for the first time levels of PFHxDA and PFOcDA were detected in the human blood at mean concentrations up to 4.22 ng/mL wb and 4.25 ng/mL wb respectively.The aim of this study was to determine concentrations of PFCAs and FTOH metabolites in blood from ski wax technicians. Keywords: FTOH, PFOA, FTCA, Precursor, Biotransformation, Ski wax |
url |
http://www.sciencedirect.com/science/article/pii/S0160412012001997 |
work_keys_str_mv |
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