Mouse models for hepatitis B virus research
Abstract Hepatitis B virus (HBV) infection remains a major global health problem; indeed, there are 250 million carriers worldwide. The host range of HBV is narrow; therefore, few primates are susceptible to HBV infection. However, ethical constraints, high cost, and large size limit the use of prim...
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doaj-4dc218e467ae48cfb4bbd916e0b6e7b12020-11-25T00:18:32ZengBMCLaboratory Animal Research2233-76602018-12-01343859110.5625/lar.2018.34.3.85Mouse models for hepatitis B virus researchJeong-Ryul Hwang0Sung-Gyoo Park1School of Life Sciences, Cwangju Institute of Science and Technology (CIST)School of Life Sciences, Cwangju Institute of Science and Technology (CIST)Abstract Hepatitis B virus (HBV) infection remains a major global health problem; indeed, there are 250 million carriers worldwide. The host range of HBV is narrow; therefore, few primates are susceptible to HBV infection. However, ethical constraints, high cost, and large size limit the use of primates as suitable animal models. Thus, in vivo testing of therapies that target HBV has been hampered by the lack of an appropriate in vivo research model. To address this, mouse model systems of HBV are being developed and several are used for studying HBV in vivo. In this review, we summarize the currently available mouse models, including HBV transgenic mice, hydrodynamic injection-mediated HBV replicon delivery systems, adeno-associated virus-mediated HBV replicon delivery systems, and human liver chimeric mouse models. These developed (or being developed) mouse model systems are promising and should be useful tools for studying HBV.http://link.springer.com/article/10.5625/lar.2018.34.3.85Hepatitis B virusmouse modelalb-uPA/SCIDFRC |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jeong-Ryul Hwang Sung-Gyoo Park |
spellingShingle |
Jeong-Ryul Hwang Sung-Gyoo Park Mouse models for hepatitis B virus research Laboratory Animal Research Hepatitis B virus mouse model alb-uPA/SCID FRC |
author_facet |
Jeong-Ryul Hwang Sung-Gyoo Park |
author_sort |
Jeong-Ryul Hwang |
title |
Mouse models for hepatitis B virus research |
title_short |
Mouse models for hepatitis B virus research |
title_full |
Mouse models for hepatitis B virus research |
title_fullStr |
Mouse models for hepatitis B virus research |
title_full_unstemmed |
Mouse models for hepatitis B virus research |
title_sort |
mouse models for hepatitis b virus research |
publisher |
BMC |
series |
Laboratory Animal Research |
issn |
2233-7660 |
publishDate |
2018-12-01 |
description |
Abstract Hepatitis B virus (HBV) infection remains a major global health problem; indeed, there are 250 million carriers worldwide. The host range of HBV is narrow; therefore, few primates are susceptible to HBV infection. However, ethical constraints, high cost, and large size limit the use of primates as suitable animal models. Thus, in vivo testing of therapies that target HBV has been hampered by the lack of an appropriate in vivo research model. To address this, mouse model systems of HBV are being developed and several are used for studying HBV in vivo. In this review, we summarize the currently available mouse models, including HBV transgenic mice, hydrodynamic injection-mediated HBV replicon delivery systems, adeno-associated virus-mediated HBV replicon delivery systems, and human liver chimeric mouse models. These developed (or being developed) mouse model systems are promising and should be useful tools for studying HBV. |
topic |
Hepatitis B virus mouse model alb-uPA/SCID FRC |
url |
http://link.springer.com/article/10.5625/lar.2018.34.3.85 |
work_keys_str_mv |
AT jeongryulhwang mousemodelsforhepatitisbvirusresearch AT sunggyoopark mousemodelsforhepatitisbvirusresearch |
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1725375978967924736 |